Phosphatidylinositol-4-phosphate 3-kinase family | Enzymes

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Phosphatidylinositol-4-phosphate 3-kinase family

Phosphatidylinositol-4-phosphate 3-kinase family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

C2α/PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) C Show summary »« Hide summary More detailed page

Target Id

2150

Nomenclature

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Common abbreviation

C2α/PIK3C2A

Previous and unofficial names

Genes

PIK3C2A (Hs), Pik3c2a (Mm), Pik3c2a (Rn)

Ensembl ID

ENSG00000011405 (Hs), ENSMUSG00000030660 (Mm), ENSRNOG00000020479 (Rn)

UniProtKB AC

O00443 (Hs), Q61194 (Mm)

EC number

2.7.1.154

Inhibitors

torin 2 pIC₅₀ 7.6 [2]

C2β/PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta) C Show summary »« Hide summary More detailed page

Target Id

2151

Nomenclature

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

Common abbreviation

C2β/PIK3C2B

Previous and unofficial names

PI3K-C2beta | PtdIns-3-kinase C2 subunit beta | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | phosphatidylinositol-4-phosphate 3-kinase

Genes

PIK3C2B (Hs), Pik3c2b (Mm), Pik3c2b (Rn)

Ensembl ID

ENSG00000133056 (Hs), ENSMUSG00000026447 (Mm), ENSRNOG00000029938 (Rn)

UniProtKB AC

O00750 (Hs)

EC number

2.7.1.154

Inhibitors

PI-103 pIC₅₀ 8.0 [1]

C2γ/PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma) C Show summary »« Hide summary More detailed page

Target Id

2288

Nomenclature

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

Common abbreviation

C2γ/PIK3C2G

Previous and unofficial names

phosphoinositide 3-kinase-C2-gamma | PI3K-C2-gamma | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma | phosphatidylinositol-4-phosphate 3-kinase | phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide

Genes

PIK3C2G (Hs), Pik3c2g (Mm), Pik3c2g (Rn)

Ensembl ID

ENSG00000139144 (Hs), ENSMUSG00000030228 (Mm), ENSRNOG00000034228 (Rn)

UniProtKB AC

O75747 (Hs), O70167 (Mm), O70173 (Rn)

EC number

2.7.1.154

References

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How to cite this family page

Database page citation:

Phosphatidylinositol-4-phosphate 3-kinase family. Accessed on 05/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=671.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.