Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)

Home
Targets
Enzymes
Kinases (EC 2.7.x.x)
Lipid modifying kinases
Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide

Type I PIP kinases are required for the production of the second messenger phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phosphorylating PtdIns(4)P [1]. This enzyme family is also known as type I PIP(5)Ks.

Enzymes

PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2164

Nomenclature

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

Common abbreviation

PIP5K1A

Previous and unofficial names

Genes

PIP5K1A (Hs), Pip5k1a (Mm), Pip5k1a (Rn)

Ensembl ID

ENSG00000143398 (Hs), ENSMUSG00000028126 (Mm), ENSRNOG00000021068 (Rn)

UniProtKB AC

Q99755 (Hs), P70182 (Mm)

EC number

2.7.1.68

Inhibitors

ISA-2011B [2]

PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2165

Nomenclature

phosphatidylinositol-4-phosphate 5-kinase type 1 gamma

Common abbreviation

PIP5K1C

Previous and unofficial names

PIP5K1-gamma | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | phosphatidylinositol-4-phosphate 5-kinase

Genes

PIP5K1C (Hs), Pip5k1c (Mm), Pip5k1c (Rn)

Ensembl ID

ENSG00000186111 (Hs), ENSMUSG00000034902 (Mm), ENSRNOG00000020577 (Rn)

UniProtKB AC

O60331 (Hs), O70161 (Mm), Q5I6B8 (Rn)

EC number

2.7.1.68

References

Show »« Hide

How to cite this family page

Database page citation:

Type I PIP kinases (1-phosphatidylinositol-4-phosphate 5-kinase family). Accessed on 21/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=675.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.