C1: Papain

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

cathepsin B Show summary »« Hide summary More detailed page

cathepsin C Show summary »« Hide summary More detailed page

cathepsin F Show summary »« Hide summary More detailed page

cathepsin H Show summary »« Hide summary More detailed page

cathepsin K Show summary »« Hide summary More detailed page

cathepsin L Show summary »« Hide summary More detailed page

Target Id

2351

Nomenclature

cathepsin L

Previous and unofficial names

Genes

CTSL (Hs), Ctsl (Mm)

Ensembl ID

ENSG00000135047 (Hs), ENSMUSG00000021477 (Mm)

UniProtKB AC

P07711 (Hs), P06797 (Mm)

EC number

3.4.22.15

cathepsin V Show summary »« Hide summary More detailed page

Target Id

2352

Nomenclature

cathepsin V

Previous and unofficial names

Genes

CTSV (Hs), Ctsl (Rn)

Ensembl ID

ENSG00000136943 (Hs), ENSRNOG00000018566 (Rn)

UniProtKB AC

O60911 (Hs), P07154 (Rn)

EC number

3.4.22.43

cathepsin S Show summary »« Hide summary More detailed page

cathepsin Z Show summary »« Hide summary More detailed page

Target Id

2354

Nomenclature

cathepsin Z

Previous and unofficial names

Genes

CTSZ (Hs), Ctsz (Mm), Ctsz (Rn)

Ensembl ID

ENSG00000101160 (Hs), ENSMUSG00000016256 (Mm), ENSRNOG00000050697 (Rn)

UniProtKB AC

Q9UBR2 (Hs), Q9WUU7 (Mm), Q9R1T3 (Rn)

EC number

3.4.18.1

References

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1. Allen JG, Fotsch C, Babij P. (2010) Emerging targets in osteoporosis disease modification. J. Med. Chem., 53 (11): 4332-53. [PMID:20218623]

2. Desmarais S, Massé F, Percival MD. (2009) Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools. Biol. Chem., 390 (9): 941-8. [PMID:19453281]

3. Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong le T, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T et al.. (2008) The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg. Med. Chem. Lett., 18 (3): 923-8. [PMID:18226527]

How to cite this family page

Database page citation:

C1: Papain. Accessed on 23/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=728.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.