M24: Methionyl aminopeptidase

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

Methionyl aminopeptidase 1 Show summary »« Hide summary More detailed page go icon to follow link

Methionyl aminopeptidase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1573

Nomenclature

Methionyl aminopeptidase 2

Previous and unofficial names

Genes

METAP2 (Hs), Metap2 (Mm), Metap2 (Rn)

Ensembl ID

ENSG00000111142 (Hs), ENSMUSG00000036112 (Mm), ENSRNOG00000021881 (Rn)

UniProtKB AC

P50579 (Hs), O08663 (Mm), P38062 (Rn)

EC number

3.4.11.18

Methionyl aminopeptidase type 1D (mitochondrial) Show summary »« Hide summary

peptidase D Show summary »« Hide summary More detailed page go icon to follow link

X-prolyl aminopeptidase 1 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1578

Nomenclature

X-prolyl aminopeptidase 1

Previous and unofficial names

Genes

XPNPEP1 (Hs), Xpnpep1 (Mm), Xpnpep1 (Rn)

Ensembl ID

ENSG00000108039 (Hs), ENSMUSG00000025027 (Mm), ENSRNOG00000012084 (Rn)

UniProtKB AC

Q9NQW7 (Hs), Q6P1B1 (Mm), O54975 (Rn)

EC number

3.4.11.9

X-prolyl aminopeptidase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1579

Nomenclature

X-prolyl aminopeptidase 2

Previous and unofficial names

Aminopeptidase P 2 | membrane-bound X-prolyl aminopeptidase | mAPP | X-prolyl aminopeptidase (aminopeptidase P) 2

Genes

XPNPEP2 (Hs), Xpnpep2 (Mm), Xpnpep2 (Rn)

Ensembl ID

ENSG00000122121 (Hs), ENSMUSG00000037005 (Mm), ENSRNOG00000004009 (Rn)

UniProtKB AC

O43895 (Hs), Q99MA2 (Rn)

EC number

3.4.11.9

Inhibitors

apstatin pK_i 6.2 [1]

X-prolyl aminopeptidase 3 Show summary »« Hide summary

References

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How to cite this family page

Database page citation:

M24: Methionyl aminopeptidase. Accessed on 12/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=746.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.