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S1: Chymotrypsin C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3194
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acrosin Show summary » More detailed page go icon to follow link

cathepsin G Show summary » More detailed page go icon to follow link

chymase 1 Show summary » More detailed page go icon to follow link

chymotrypsin C Show summary » More detailed page go icon to follow link

chymotrypsin like Show summary » More detailed page go icon to follow link

chymotrypsin like elastase 1 Show summary » More detailed page go icon to follow link

chymotrypsin like elastase 2A Show summary » More detailed page go icon to follow link

complement C1r C Show summary » More detailed page go icon to follow link

complement C1s Show summary » More detailed page go icon to follow link

complement factor B Show summary » More detailed page go icon to follow link

coagulation factor II, thrombin / prothrombin C Show summary » More detailed page go icon to follow link

coagulation factor VII Show summary » More detailed page go icon to follow link

coagulation factor IX Show summary » More detailed page go icon to follow link

coagulation factor X C Show summary » More detailed page go icon to follow link

coagulation factor XI Show summary » More detailed page go icon to follow link

coagulation factor XII Show summary » More detailed page go icon to follow link

elastase, neutrophil expressed C Show summary » More detailed page go icon to follow link

granzyme A Show summary » More detailed page go icon to follow link

granzyme B Show summary » More detailed page go icon to follow link

granzyme K Show summary » More detailed page go icon to follow link

HtrA serine peptidase 1 Show summary »


Target Id 3194
Nomenclature HtrA serine peptidase 1
Previous and unofficial names ARMD7 | high temperature requirement A1 peptidase | IGF-binding serine protease | protease, serine, 11 (IGF binding) | PRSS11
Genes HTRA1 (Hs), Htra1 (Mm), Htra1 (Rn)
Ensembl ID ENSG00000166033 (Hs), ENSMUSG00000006205 (Mm), ENSRNOG00000020533 (Rn)
UniProtKB AC Q92743 (Hs), Q9R118 (Mm), Q9QZK5 (Rn)
Antibodies
galegenimab (Inhibition) pKd 9.2 [17]
Comment HTRA1 is a serine protease that cleaves a variety of substrates including insulin-like growth factor (IGF)-binding proteins (a mechanism that regulates the availability of IGFs), TGFβ family proteins, fibronectin, amyloid precursor protein and Dickkop-related protein 3 (DKK3), and a number of additional extracellular matrix proteins [19]. Genetic variants are associated with age-related degeneration [12], cerebral small vessel disease [3,22,29], and cancer [1,36,41].

kallikrein B1 Show summary » More detailed page go icon to follow link

kallikrein 1 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 2 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 3 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 4 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 5 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 6 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 7 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 8 Show summary » More detailed page go icon to follow link

kallikrein related peptidase 14 Show summary » More detailed page go icon to follow link

plasminogen C Show summary » More detailed page go icon to follow link

plasminogen activator, tissue type C Show summary » More detailed page go icon to follow link

plasminogen activator, urokinase Show summary » More detailed page go icon to follow link

serine protease 1 C Show summary » More detailed page go icon to follow link

serine protease 2 Show summary » More detailed page go icon to follow link

serine protease 3 Show summary » More detailed page go icon to follow link

serine protease 8 Show summary » More detailed page go icon to follow link

protein C, inactivator of coagulation factors Va and VIIIa Show summary » More detailed page go icon to follow link

proteinase 3 Show summary » More detailed page go icon to follow link

ST14 transmembrane serine protease matriptase Show summary » More detailed page go icon to follow link

transmembrane serine protease 2 C Show summary » More detailed page go icon to follow link

transmembrane serine protease 6 Show summary » More detailed page go icon to follow link

transmembrane serine protease 11D Show summary » More detailed page go icon to follow link

transmembrane serine protease 15 Show summary »

tryptase alpha/beta 1 C Show summary » More detailed page go icon to follow link

tryptase gamma 1 Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

S1: Chymotrypsin. Accessed on 02/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=751.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.