Alkaline ceramidases | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Ceramide turnover
Alkaline ceramidases

Alkaline ceramidases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The six human ceramidases may be divided on the basis of pH optimae into acid, neutral and alkaline ceramidases, which also differ in their subcellular location.

Enzymes

alkaline ceramidase 1 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2468

Nomenclature

alkaline ceramidase 1

Previous and unofficial names

Acylsphingosine deacylase 3 | Alkaline CDase 1 | AlkCDase 1 | ASAH3 | Cer1

Genes

ACER1 (Hs), Acer1 (Mm), Acer1 (Rn)

Ensembl ID

ENSG00000167769 (Hs), ENSMUSG00000045019 (Mm), ENSRNOG00000047368 (Rn)

UniProtKB AC

Q8TDN7 (Hs), Q8R4X1 (Mm)

EC number

3.5.1.23

ceramide -> sphingosine + a fatty acid

Comment

ACER1 is associated with the ER [2].

alkaline ceramidase 2 C Show summary »« Hide summary

Target Id

2469

Nomenclature

alkaline ceramidase 2

Previous and unofficial names

Alkaline CDase 2 | AlkCDase 2 | ASAH3L | Cancer-related gene liver 1 protein | CRG-L1

Genes

ACER2 (Hs), Acer2 (Mm), Acer2 (Rn)

Ensembl ID

ENSG00000177076 (Hs), ENSMUSG00000038007 (Mm), ENSRNOG00000007637 (Rn)

UniProtKB AC

Q5QJU3 (Hs), Q8VD53 (Mm)

EC number

3.5.1.23

ceramide -> sphingosine + a fatty acid

Comment

ACER2 is associated with the Golgi apparatus [3].

alkaline ceramidase 3 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2470

Nomenclature

alkaline ceramidase 3

Previous and unofficial names

Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase

Genes

ACER3 (Hs), Acer3 (Mm), Acer3 (Rn)

Ensembl ID

ENSG00000078124 (Hs), ENSMUSG00000030760 (Mm), ENSRNOG00000036866 (Rn)

UniProtKB AC

Q9NUN7 (Hs), Q9D099 (Mm)

EC number

3.5.1.-

Comment

ACER3 is associated with the ER and Golgi apparatus [1].

References

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1. Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM. (2001) Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem, 276 (28): 26577-88. [PMID:11356846]

2. Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C. (2008) Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. J Invest Dermatol, 128 (2): 389-97. [PMID:17713573]

3. Xu R, Jin J, Hu W, Sun W, Bielawski J, Szulc Z, Taha T, Obeid LM, Mao C. (2006) Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J, 20 (11): 1813-25. [PMID:16940153]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.