Neutral ceramidases | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Ceramide turnover
Neutral ceramidases

Neutral ceramidases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The six human ceramidases may be divided on the basis of pH optimae into acid, neutral and alkaline ceramidases, which also differ in their subcellular location.

Enzymes

N-acylsphingosine amidohydrolase 2 C Show summary »« Hide summary

Target Id

2492

Nomenclature

N-acylsphingosine amidohydrolase 2

Previous and unofficial names

Genes

ASAH2 (Hs), Asah2 (Mm), Asah2 (Rn)

Ensembl ID

ENSG00000188611 (Hs), ENSMUSG00000024887 (Mm), ENSRNOG00000012196 (Rn)

UniProtKB AC

Q9NR71 (Hs), Q9JHE3 (Mm), Q91XT9 (Rn)

EC number

3.5.1.23

ceramide -> sphingosine + a fatty acid

Comment

The enzyme is associated with the plasma membrane [1].

N-acylsphingosine amidohydrolase 2B C Show summary »« Hide summary

Target Id	2493
Nomenclature	N-acylsphingosine amidohydrolase 2B
Previous and unofficial names	ASAH2-like protein \| N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B
Genes	ASAH2B (Hs)
Ensembl ID	ENSG00000204147 (Hs)
UniProtKB AC	P0C7U1 (Hs)

Comments

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References

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.