Sphingosine 1-phosphate phosphatase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

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Sphingosine 1-phosphate turnover
Sphingosine 1-phosphate phosphatase

Sphingosine 1-phosphate phosphatase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

SGPP1 (sphingosine-1-phosphate phosphatase 1) C Show summary »« Hide summary

Target Id

2523

Nomenclature

sphingosine-1-phosphate phosphatase 1

Common abbreviation

SGPP1

Previous and unofficial names

Spp1 | SPPase1

Genes

SGPP1 (Hs), Sgpp1 (Mm), Sgpp1 (Rn)

Ensembl ID

ENSG00000126821 (Hs), ENSMUSG00000021054 (Mm), ENSRNOG00000005175 (Rn)

UniProtKB AC

Q9BX95 (Hs), Q9JI99 (Mm), Q99P55 (Rn)

EC number

3.1.3.-

Sphingosine 1-phosphate -> sphingosine + inorganic phosphate

Comment

Depletion of S1P phosphohydrolase-1 (SPP1), which degrades intracellular S1P, induces the unfolded protein response and endoplasmic reticulum stress-induced autophagy [1].

SGPP2 (sphingosine-1-phosphate phosphatase 2) C Show summary »« Hide summary

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Susan Pyne. Sphingosine 1-phosphate phosphatase. Accessed on 15/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=778.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.