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Heat shock proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Targets

3193
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heat shock protein family A (Hsp70) member 1A Show summary »

heat shock protein family A (Hsp70) member 1B Show summary »

heat shock protein family A (Hsp70) member 2 Show summary »

heat shock protein family A (Hsp70) member 5 Show summary »


Target Id 3193
Nomenclature heat shock protein family A (Hsp70) member 5
Previous and unofficial names BiP | glucose-regulated protein, 78kDa | GRP78 | HEL-S-89n
Genes HSPA5 (Hs), Hspa5 (Mm), Hspa5 (Rn)
Ensembl ID ENSG00000044574 (Hs), ENSMUSG00000026864 (Mm), ENSRNOG00000018294 (Rn)
UniProtKB AC P11021 (Hs), P20029 (Mm), P06761 (Rn)
Comment HSPA5 is a typical HSP70 chaperone that is involved in the folding and assembly of proteins at the endoplasmic reticulum. The protein is considered as a potential therapeutic target for viral infections [1,7-8], chemoresistant cancers and inflammation.

heat shock protein family A (Hsp70) member 6 Show summary »

heat shock protein family A (Hsp70) member 8 Show summary »

heat shock protein family A (Hsp70) member 1 like / HSPA1L Show summary » More detailed page go icon to follow link

HSP90B1 (heat shock protein 90 beta family member 1) Show summary » More detailed page go icon to follow link

HSP90AA1 (heat shock protein 90 alpha family class A member 1) Show summary » More detailed page go icon to follow link

HSP90AB1 (heat shock protein 90 alpha family class B member 1) Show summary » More detailed page go icon to follow link

TRAP1 (TNF receptor associated protein 1) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Heat shock proteins. Accessed on 29/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=784.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.