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Sphingolipid Δ4-desaturase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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DEGS1 and DEGS2 are 4TM proteins.

Enzymes

2484
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delta 4-desaturase, sphingolipid 1 C Show summary »

Target Id 2484
Nomenclature delta 4-desaturase, sphingolipid 1
Previous and unofficial names Cell migration-inducing gene 15 protein | degenerative spermatocyte homolog 1 (Drosophila) | Degs | delta(4)-desaturase | delta(4)-desaturase, sphingolipid 1 | DES1 | dihydroceramide desaturase-1 | FADS7 | Mdes | Membrane lipid desaturase | MLD
Genes DEGS1 (Hs), Degs1 (Mm), Degs1 (Rn)
Ensembl ID ENSG00000143753 (Hs), ENSMUSG00000038633 (Mm), ENSRNOG00000003223 (Rn)
UniProtKB AC O15121 (Hs), O09005 (Mm), Q5XIF5 (Rn)
EC number
1.14.-.-
Cofactors
NAD
Inhibitors
SKI II pKi 6.5 [3]
RBM2-1B pIC50 4.7 [2]
Comment Myristoylation of DEGS1 enhances its activity and targets it to the mitochondria [1].

delta 4-desaturase, sphingolipid 2 C Show summary »

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.