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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The ROS1 gene encodes a receptor tyrosine kinase, whose endogenous substrate and normal physiological functions are not fully determined. Aberrant expression and mutated forms of ROS1 are drivers of malignant transformation in number of tumour types.
ROS (c-ros oncogene 1, receptor tyrosine kinase)
C
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Database page citation:
Type XVII RTKs: ROS receptors. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=796.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. Br J Pharmacol. 178 Suppl 1:S264-S312.
Crizotinib is a tyrosine kinase inhibitor, anti-cancer drug targeting ALK and ROS1.