2.1.2.- Hydroxymethyl-, formyl- and related transferases

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2.1.2.- Hydroxymethyl-, formyl- and related transferases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2612

Nomenclature

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Common abbreviation

GART

Previous and unofficial names

PGFT | PRGS | trifunctional purine biosynthetic protein adenosine-3 | phosphoribosylglycinamide formyltransferase

Genes

GART (Hs), Gart (Mm), Gart (Rn)

Ensembl ID

ENSG00000159131 (Hs), ENSMUSG00000022962 (Mm), ENSRNOG00000028292 (Rn)

UniProtKB AC

P22102 (Hs), Q64737 (Mm)

EC number

2.1.2.2

6.3.3.1

6.3.4.13

Inhibitors

pemetrexed pK_i 5.0 [1] - Mouse

References

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How to cite this family page

Database page citation:

2.1.2.- Hydroxymethyl-, formyl- and related transferases. Accessed on 01/07/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=846.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.