5.-.-.- Isomerases

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5.-.-.- Isomerases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3293

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2622

Nomenclature

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Previous and unofficial names

3 beta-hydroxysteroid dehydrogenase/Delta 5 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | hydroxy-delta-5-steroid dehydrogenase

Genes

HSD3B2 (Hs), Hsd3b1 (Mm), Hsd3b1 (Rn)

Ensembl ID

ENSG00000203859 (Hs), ENSMUSG00000027871 (Mm), ENSRNOG00000070622 (Rn)

UniProtKB AC

P26439 (Hs), P24815 (Mm)

EC number

1.1.1.145

5.3.3.1

Inhibitors

trilostane pIC₅₀ 8.4 (Note that the species is not specified in the referenced article.) [7]

PDIA3 (protein disulfide isomerase family A member 3) Show summary »« Hide summary

Target Id

3293

Nomenclature

protein disulfide isomerase family A member 3

Common abbreviation

PDIA3

Previous and unofficial names

glucose regulated protein, 58kDa (GRP58) | protein disulfide isomerase-associated 3 | ERp57

Genes

PDIA3 (Hs), Pdia3 (Mm), Pdia3 (Rn)

Ensembl ID

ENSG00000167004 (Hs), ENSRNOG00000015018 (Rn)

UniProtKB AC

P30101 (Hs), P27773 (Mm), P11598 (Rn)

EC number

5.3.4.1

Inhibitors

punicalagin pK_i 6.5 [3]

punicalagin pIC₅₀ 5.8 [6]

Comment

PDIA3 is a multifunctional enzyme that catalyses formation of disulfide bonds and regulates thiol groups on target proteins through disulfide isomerase and thiol-oxidoreductase activities respectively [2,4]. It facilitates folding of newly synthesised glycoproteins in the endoplasmic reticulum in association with the lectin chaperones calreticulin and calnexin. Abberant expression has been detected in cancers and downregulation/inhibition has antitumour effects [1,5,8-9].

References

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1. Abdullatif A, Abdelrahman AE, Bakry A, Gharieb SA, Ramadan MS, Wasfy MA, Abdelwanis AH, Fouad EM. (2024) Clinicopathological significance of protein disulphide isomerase A3 and phosphorylated signal transducer and activator of transcription 3 in cervical carcinoma. Contemp Oncol (Pozn), 28 (1): 51-62. [PMID:38800530]

2. Frickel EM, Frei P, Bouvier M, Stafford WF, Helenius A, Glockshuber R, Ellgaard L. (2004) ERp57 is a multifunctional thiol-disulfide oxidoreductase. J Biol Chem, 279 (18): 18277-87. [PMID:14871896]

3. Giamogante F, Marrocco I, Cervoni L, Eufemi M, Chichiarelli S, Altieri F. (2018) Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity. Biochimie, 147: 122-129. [PMID:29425676]

4. Hettinghouse A, Liu R, Liu CJ. (2018) Multifunctional molecule ERp57: From cancer to neurodegenerative diseases. Pharmacol Ther, 181: 34-48. [PMID:28723413]

5. Kermpatsou D, Olsson F, Wåhlén E, Söderberg O, Lennartsson J, Norlin M. (2024) Cellular responses to silencing of PDIA3 (protein disulphide-isomerase A3): Effects on proliferation, migration, and genes in control of active vitamin D. J Steroid Biochem Mol Biol, 240: 106497. [PMID:38460707]

6. Paglia G, Antonini L, Cervoni L, Ragno R, Sabatino M, Minacori M, Rubini E, Altieri F. (2021) A Comparative Analysis of Punicalagin Interaction with PDIA1 and PDIA3 by Biochemical and Computational Approaches. Biomedicines, 9 (11). [PMID:34829762]

7. Rabe T, Kiesel L, Kellermann J, Weidenhammer K, Runnebaum B, Potts GO. (1983) Inhibition of human placental progesterone synthesis and aromatase activity by synthetic steroidogenic inhibitors in vitro. Fertil Steril, 39 (6): 829-35. [PMID:6574022]

8. Wang L, Wang X, Zhang J, Duan J, Tang C, Zhang L, Zeng H, Li H, Li Y, Zhou Y. (2023) The role of PDIA3 in oral squamous cell carcinoma and its value as A diagnostic and prognostic biomarker. Heliyon, 9 (12): e22596. [PMID:38213579]

9. Yang M, Li Q, Yang H, Li Y, Lu L, Wu X, Liu Y, Li W, Shen J, Xiao Z et al.. (2024) Downregulation of PDIA3 inhibits gastric cancer cell growth through cell cycle regulation. Biomed Pharmacother, 173: 116336. [PMID:38412717]

How to cite this family page

Database page citation:

5.-.-.- Isomerases. Accessed on 24/03/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=849.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.

5.-.-.- Isomerases

Enzymes

Further reading

References

How to cite this family page