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CD molecules C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Cluster of differentiation refers to an attempt to catalogue systematically a series of over 300 cell-surface proteins associated with immunotyping. Many members of the group have identified functions as enzymes (for example, see CD73 ecto-5'-nucleotidase) or receptors (for example, see CD41 integrin, alpha 2b subunit). Many CDs are targeted for therapeutic gain using antibodies for the treatment of proliferative disorders. A full listing of all the Clusters of Differentiation proteins is not possible in the Guide to PHARMACOLOGY; listed herein are selected members of the family targeted for therapeutic gain.

Targets

3196
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CD1d molecule Show summary » More detailed page go icon to follow link

CD2 C Show summary » More detailed page go icon to follow link

CD3e C Show summary » More detailed page go icon to follow link

CD4 Show summary » More detailed page go icon to follow link

CD6 C Show summary » More detailed page go icon to follow link

CD14 molecule Show summary » More detailed page go icon to follow link

Fc fragment of IgG receptor IIIa / CD16A Show summary » More detailed page go icon to follow link

CD19 Show summary » More detailed page go icon to follow link

CD20 (membrane-spanning 4-domains, subfamily A, member 1) C Show summary » More detailed page go icon to follow link

SIGLEC2 (CD22) Show summary » More detailed page go icon to follow link

CD24 molecule Show summary » More detailed page go icon to follow link

CD28 Show summary » More detailed page go icon to follow link

SIGLEC3 (CD33) C Show summary » More detailed page go icon to follow link

CD36 molecule Show summary » More detailed page go icon to follow link

CD37 (CD37 molecule) Show summary » More detailed page go icon to follow link

CD38 Show summary » More detailed page go icon to follow link

CD47 Show summary » More detailed page go icon to follow link

CD52 C Show summary » More detailed page go icon to follow link

NCAM1 (neural cell adhesion molecule 1 (CD56)) Show summary » More detailed page go icon to follow link

selectin P (CD62) Show summary » More detailed page go icon to follow link

selectin E (CD62E) Show summary »

CD66e (CEACAM5) Show summary » More detailed page go icon to follow link

transferrin receptor (CD71) Show summary »


Target Id 3196
Nomenclature transferrin receptor (CD71)
Previous and unofficial names CD71 | TfR1
Genes TFRC (Hs), Tfrc (Mm), Tfrc (Rn)
Ensembl ID ENSG00000072274 (Hs), ENSMUSG00000022797 (Mm), ENSRNOG00000001766 (Rn)
UniProtKB AC P02786 (Hs), Q62351 (Mm), Q99376 (Rn)
Antibodies
pabinafusp alfa (Binding) [31-32]
lepunafusp alfa (Binding) [31]
Comment The transferrin receptor (TFRC) is a membrane protein that is required for erythropoiesis, neurologic development and cellular iron homeostasis. It carries transferrin-iron complexes into cells via receptor-mediated endocytosis.
The TFRC is being leveraged as a mechanism do enable site-specific drug delivery, including drug delivery across the blood-brain barrier (BBB) [10,27,36].

CD74 Show summary » More detailed page go icon to follow link

CD79B Show summary » More detailed page go icon to follow link

CD80 C Show summary » More detailed page go icon to follow link

LILRB1 (leukocyte immunoglobulin like receptor B1 (CD85j)) Show summary » More detailed page go icon to follow link

LILRA4 (leukocyte immunoglobulin like receptor A4 (CD85g)) Show summary » More detailed page go icon to follow link

CD86 C Show summary » More detailed page go icon to follow link

FcαRI (Fc fragment of IgA receptor / CD89) Show summary » More detailed page go icon to follow link

semaphorin 4D (CD100) Show summary » More detailed page go icon to follow link

endoglin (CD105) Show summary » More detailed page go icon to follow link

basigin (Ok blood group) / CD147 Show summary » More detailed page go icon to follow link

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4 (CD152)) C Show summary » More detailed page go icon to follow link

KIR3DL2 (CD158K) Show summary » More detailed page go icon to follow link

NKG2A (killer cell lectin like receptor C1 (CD159a) / CD159a) Show summary » More detailed page go icon to follow link

KLRC2 (killer cell lectin like receptor C2 (CD159c) / CD159c) Show summary »

SIRPA (CD172a) Show summary » More detailed page go icon to follow link

LAG3 (CD223) / CD223 Show summary » More detailed page go icon to follow link

T-cell surface glycoprotein CD3 zeta chain (CD247) Show summary » More detailed page go icon to follow link

B7-H3 (CD276) Show summary » More detailed page go icon to follow link

ICOS (CD278) Show summary » More detailed page go icon to follow link

PD-1 (programmed cell death 1 (CD279)) C Show summary » More detailed page go icon to follow link

CD300a C Show summary » More detailed page go icon to follow link

LAIR1 (leukocyte associated immunoglobulin like receptor 1 (CD305)) Show summary » More detailed page go icon to follow link

CS1 (CD319) Show summary » More detailed page go icon to follow link

NKp30 (Natural cytotoxicity triggering receptor 3 (CD337)) Show summary » More detailed page go icon to follow link

TIM3 (CD366) Show summary » More detailed page go icon to follow link

Comments

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Further reading

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References

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How to cite this family page

Database page citation:

CD molecules. Accessed on 05/07/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=852.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.