Methyllysine reader proteins | Other protein targets | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Methyllysine reader proteins C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

Methyllysine reader proteins bind to methylated proteins, such as histones, allowing regulation of gene expression.

Targets

Click here for help

L3MBTL histone methyl-lysine binding protein 3 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2830

Nomenclature

L3MBTL histone methyl-lysine binding protein 3

Previous and unofficial names

L3MBTL3 | L3MBTL3, histone methyl-lysine binding protein | l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1

Genes

L3MBTL3 (Hs), L3mbtl3 (Mm), L3mbtl3 (Rn)

Ensembl ID

ENSG00000198945 (Hs), ENSMUSG00000039089 (Mm), ENSRNOG00000011720 (Rn)

UniProtKB AC

Q96JM7 (Hs), Q8BLB7 (Mm)

Selective agonists

UNC1215 [1]

Further reading

Click here for help

* Key recommended reading is highlighted with an asterisk

* Barghout SH, Machado RAC, Barsyte-Lovejoy D. (2022) Chemical biology and pharmacology of histone lysine methylation inhibitors. Biochim Biophys Acta Gene Regul Mech, 1865 (6): 194840. [PMID:35753676]

Daskalaki MG, Tsatsanis C, Kampranis SC. (2018) Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. J Cell Physiol, 233 (9): 6495-6507. [PMID:29574768]

* Furuya K, Ikura M, Ikura T. (2019) Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis. J Biochem, 165 (4): 297-299. [PMID:30605533]

* Levy D. (2019) Lysine methylation signaling of non-histone proteins in the nucleus. Cell Mol Life Sci, 76 (15): 2873-2883. [PMID:31123776]

* Li J, Ahn JH, Wang GG. (2019) Understanding histone H3 lysine 36 methylation and its deregulation in disease. Cell Mol Life Sci, 76 (15): 2899-2916. [PMID:31147750]

Liu K, Liu Y, Lau JL, Min J. (2015) Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacol Ther, 151: 121-40. [PMID:25857453]

Milosevich N, Hof F. (2016) Chemical Inhibitors of Epigenetic Methyllysine Reader Proteins. Biochemistry, 55 (11): 1570-83. [PMID:26650180]

Musselman CA, Khorasanizadeh S, Kutateladze TG. (2014) Towards understanding methyllysine readout. Biochim Biophys Acta, 1839 (8): 686-93. [PMID:24727128]

Sadakierska-Chudy A, Kostrzewa RM, Filip M. (2015) A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants. Neurotox Res, 27 (1): 84-97. [PMID:25362550]

* Shafabakhsh R, Aghadavod E, Ghayour-Mobarhan M, Ferns G, Asemi Z. (2019) Role of histone modification and DNA methylation in signaling pathways involved in diabetic retinopathy. J Cell Physiol, 234 (6): 7839-7846. [PMID:30515789]

Teske KA, Hadden MK. (2017) Methyllysine binding domains: Structural insight and small molecule probe development. Eur J Med Chem, 136: 14-35. [PMID:28478342]

Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. (2014) Targeting histone lysine demethylases - progress, challenges, and the future. Biochim Biophys Acta, 1839 (12): 1416-32. [PMID:24859458]

Zahnow CA, Topper M, Stone M, Murray-Stewart T, Li H, Baylin SB, Casero Jr RA. (2016) Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy. Adv Cancer Res, 130: 55-111. [PMID:27037751]

References

Click here for help

How to cite this family page

Database page citation:

Methyllysine reader proteins. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=902.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.