Tumour-associated antigens

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Tumour-associated antigens

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Targets

glypican 3 Show summary »« Hide summary More detailed page go icon to follow link

trophoblast glycoprotein Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3009
Nomenclature	trophoblast glycoprotein
Previous and unofficial names	5T4 \| 5T4-Ag \| 5T4 oncofetal antigen \| Wnt-activated inhibitory factor 1 \| WAIF1
Genes	TPBG (Hs), Tpbg (Mm), Tpbg (Rn)
Ensembl ID	ENSG00000146242 (Hs), ENSMUSG00000035274 (Mm), ENSRNOG00000010694 (Rn)
UniProtKB AC	Q13641 (Hs), Q9Z0L0 (Mm), Q5PQV5 (Rn)
Comment	Trophoblast glycoprotein (a.k.a. 5T4 oncofetal antigen) is a 72-kDa oncofetal protein whose expression on trophoblast cells mediates survival of the foetus as a semi-allograft in the mother, and is overexpressed in several cancer types where it allows the tumour to evade immune surveillance by the host.

tumor associated calcium signal transducer 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2837
Nomenclature	tumor associated calcium signal transducer 2
Previous and unofficial names	M1S1 \| EGP-1 \| TROP2 \| TROP-2 \| GA733-1 \| RS7 antigen [1] \| tumor-associated calcium signal transducer 2
Genes	TACSTD2 (Hs), Tacstd2 (Mm), Tacstd2 (Rn)
Ensembl ID	ENSG00000184292 (Hs), ENSMUSG00000051397 (Mm), ENSRNOG00000007740 (Rn)
UniProtKB AC	P09758 (Hs), Q8BGV3 (Mm), Q6P9Z6 (Rn)

References

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How to cite this family page

Database page citation:

Tumour-associated antigens. Accessed on 09/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=904.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.