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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
SAP is a member of the pentraxin protein family.
SAP [7] is a constitutively expressed vertebrate protein [9] found in all types of amyloid deposits [10-11], in glomerular basement membrane [3] and in elastic fibres in blood vessels [2]. SAP binding is calcium-dependent [8]. It is suggested that SAP binding may have an important role to play in atherosclerosis [6,12] and amyloidosis [1,14]. The identification of SAP as a player in amyloidoses and neuropathies, and in response to proof of concept studies [4], this protein is now a drug discovery target [5].
amyloid P component, serum
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Database page citation:
Serum pentraxins. Accessed on 29/09/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=907.
Concise Guide to PHARMACOLOGY citation:
Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.