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1.4.3.13 Lysyl oxidases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Lysyl oxidases are extracellular enzymes that are vital for cross-linking fibrillar elastin and collagens and for extracellular matrix stabilisation [2,5,5]. LOX and LOXL2 are implicated in fibrosis, tumourigenesis, and metastasis [1], and are subsequently molecular targets for cancer drug discovery [6].

Enzymes

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lysyl oxidase Show summary » More detailed page go icon to follow link

lysyl oxidase like 2 Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

1.4.3.13 Lysyl oxidases. Accessed on 07/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=912.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.