Mitochondrial-associated proteins

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Mitochondrial-associated proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Targets

Translocator protein Show summary »« Hide summary

Target Id

2879

Nomenclature

Translocator protein

Previous and unofficial names

Mitochondrial benzodiazepine receptor | Peripheral-type benzodiazepine receptor | translocator protein (18kDa)

Genes

TSPO (Hs), Tspo (Mm), Tspo (Rn)

Ensembl ID

ENSG00000100300 (Hs), ENSMUSG00000041736 (Mm), ENSRNOG00000010549 (Rn)

UniProtKB AC

P30536 (Hs), P50637 (Mm), P16257 (Rn)

Ligands

BAY-069 (Binding) pK_i 7.1 [3] - Rat

Selective ligands

PK 11195 (Binding) pK_i 8.1 [1]

Selective agonists

emapunil [2] - Rat

References

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1. Damont A, Boisgard R, Kuhnast B, Lemée F, Raggiri G, Scarf AM, Da Pozzo E, Selleri S, Martini C, Tavitian B et al.. (2011) Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg Med Chem Lett, 21 (16): 4819-22. [PMID:21741237]

2. Yanamoto K, Kumata K, Yamasaki T, Odawara C, Kawamura K, Yui J, Hatori A, Suzuki K, Zhang MR. (2009) [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. Bioorg Med Chem Lett, 19 (6): 1707-10. [PMID:19217778]

3. Data for DCP probe BAY-069. Accessed on 21/10/2022. Modified on 21/10/2022. www.ebi.ac.uk/chembl, . DOI: 10.6019/CHEMBL4507325

How to cite this family page

Database page citation:

Mitochondrial-associated proteins. Accessed on 10/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=919.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets. Br J Pharmacol. 178 Suppl 1:S1-S26.