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Other immune checkpoint proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Checkpoint proteins include co-inhibitory and co-stimulatory receptors on immune effectors cells. Blocking monoclonal antibodies (mAbs) to co-inhibitory receptors such as PD-1 and CTLA4 have sucessfully entered clinical practice as cancer immunotherapies. Co-stimulatory receptors such as GITR, ICOS and OX40 are being targeted by immunostimulatory mAbs in preclinical and clinical development programmes [3,13].

Targets

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SIGLEC2 (CD22) Show summary » More detailed page go icon to follow link

CD28 Show summary » More detailed page go icon to follow link

SIGLEC3 (CD33) C Show summary » More detailed page go icon to follow link

CD80 C Show summary » More detailed page go icon to follow link

LILRB1 (leukocyte immunoglobulin like receptor B1 (CD85j)) Show summary » More detailed page go icon to follow link

CD86 C Show summary » More detailed page go icon to follow link

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4 (CD152)) C Show summary » More detailed page go icon to follow link

LAG3 (CD223) / CD223 Show summary » More detailed page go icon to follow link

B7-H3 (CD276) Show summary » More detailed page go icon to follow link

ICOS (CD278) Show summary » More detailed page go icon to follow link

PD-1 (programmed cell death 1 (CD279)) C Show summary » More detailed page go icon to follow link

TIM3 (CD366) Show summary » More detailed page go icon to follow link

ILDR2 (immunoglobulin like domain containing receptor 2) Show summary » More detailed page go icon to follow link

PVRIG (PVR related immunoglobulin domain containing) Show summary » More detailed page go icon to follow link

TIGIT Show summary » More detailed page go icon to follow link

VISTA (V-set immunoregulatory receptor) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Other immune checkpoint proteins. Accessed on 22/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=949.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.