Immunoglobulin like domain containing proteins

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Immunoglobulin like domain containing proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Targets

RAGE (advanced glycosylation end-product specific receptor) Show summary »« Hide summary More detailed page

Target Id

2843

Nomenclature

advanced glycosylation end-product specific receptor

Common abbreviation

RAGE

Previous and unofficial names

advanced glycosylation end product-specific receptor

Genes

AGER (Hs), Ager (Mm), Ager (Rn)

Ensembl ID

ENSG00000204305 (Hs), ENSMUSG00000015452 (Mm), ENSRNOG00000000439 (Rn)

UniProtKB AC

Q15109 (Hs), Q62151 (Mm), Q63495 (Rn)

Antagonists

azeliragon pIC₅₀ ~6.0 [2,4]

Comment

RAGE is a single chain, membrane bound immunoglobulin type protein [3,5-6] which acts as a pattern recognition receptor for ligands containing a common glycation motif.

FcαRI (Fc fragment of IgA receptor / CD89) Show summary »« Hide summary More detailed page

Target Id	2991
Nomenclature	Fc fragment of IgA receptor
Systematic nomenclature	CD89
Common abbreviation	FcαRI
Genes	FCAR (Hs), Fcar (Rn)
Ensembl ID	ENSG00000186431 (Hs), ENSRNOG00000027855 (Rn)
UniProtKB AC	P24071 (Hs)

FcμRI (Fc fragment of IgM receptor) Show summary »« Hide summary More detailed page

MALT1 paracaspase Show summary »« Hide summary More detailed page

Target Id	2983
Nomenclature	MALT1 paracaspase
Previous and unofficial names	MLT \| mucosa associated lymphoid tissue lymphoma translocation gene 1 \| Pcasp1 \| MALT1 protease
Genes	MALT1 (Hs), Malt1 (Mm), Malt1 (Rn)
Ensembl ID	ENSG00000172175 (Hs), ENSMUSG00000032688 (Mm), ENSRNOG00000017181 (Rn)
UniProtKB AC	Q9UDY8 (Hs), Q2TBA3 (Mm)

TIGIT Show summary »« Hide summary More detailed page

Target Id	2941
Nomenclature	TIGIT
Previous and unofficial names	T-cell immunoreceptor with Ig and ITIM domains \| V-set and immunoglobulin domain containing 9 \| V-set and transmembrane domain containing 3 \| VSIG9 \| VSTM3 \| WUCAM [1]
Genes	TIGIT (Hs), Tigit (Mm), Tigit (Rn)
Ensembl ID	ENSG00000181847 (Hs), ENSMUSG00000071552 (Mm), ENSRNOG00000056574 (Rn)
UniProtKB AC	Q495A1 (Hs), P86176 (Mm)

Fc fragment of IgG receptor IIIa / CD16A Show summary »« Hide summary More detailed page

Target Id	3017
Nomenclature	Fc fragment of IgG receptor IIIa
Systematic nomenclature	CD16A
Previous and unofficial names	Fc receptor, IgG, low affinity IV \| Fc receptor \| FCγRIIIa \| FcRIIIA \| low affinity immunoglobulin gamma Fc region receptor III-A
Genes	FCGR3A (Hs), Fcgr4 (Mm), Fcgr3a (Rn)
Ensembl ID	ENSG00000203747 (Hs), ENSMUSG00000059089 (Mm), ENSRNOG00000024382 (Rn)
UniProtKB AC	P08637 (Hs), A0A0B4J1G0 (Mm)

CD155 (PVR cell adhesion molecule) Show summary »« Hide summary More detailed page

Target Id	3095
Nomenclature	PVR cell adhesion molecule
Common abbreviation	CD155
Previous and unofficial names	CD155 \| NECL5 \| nectin-like 5 \| poliovirus receptor \| Tage4
Genes	PVR (Hs)
Ensembl ID	ENSG00000073008 (Hs)
UniProtKB AC	P15151 (Hs)
Comment	PVR is the receptor that is expoited by the poliovirus to gain entry to host cells. It also contributes to a number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors.

References

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1. Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. (2009) A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur. J. Immunol., 39 (3): 695-703. [PMID:19197944]

2. Mjalli A, Andrews R, Shen J, Rothlein R. (2005) Rage antagonists as agents to reverse amyloidosis and diseases associated therewith. Patent number: US20050026811 A1. Assignee: Mjalli A, Andrews R, Shen J, Rothlein R. Priority date: 20/05/2003. Publication date: 03/02/2005.

3. Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, Elliston K, Stern D, Shaw A. (1992) Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem., 267 (21): 14998-5004. [PMID:1378843]

4. Saito S, Ihara M. (2014) New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. Front Aging Neurosci, 6: 290. [PMID:25368578]

5. Schmidt AM, Hori O, Cao R, Yan SD, Brett J, Wautier JL, Ogawa S, Kuwabara K, Matsumoto M, Stern D. (1996) RAGE: a novel cellular receptor for advanced glycation end products. Diabetes, 45 Suppl 3: S77-80. [PMID:8674899]

6. Yan SD, Stern D, Schmidt AM. (1997) What's the RAGE? The receptor for advanced glycation end products (RAGE) and the dark side of glucose. Eur. J. Clin. Invest., 27 (3): 179-81. [PMID:9088851]

How to cite this family page

Database page citation:

Immunoglobulin like domain containing proteins. Accessed on 24/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=984.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.