Top ▲

NADPH oxidases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide More detailed introduction go icon to follow link

The two DUOX enzymes were originally identified as participating in the production of hydrogen peroxide as a pre-requisite for thyroid hormone biosynthesis in the thyroid gland [1].
NOX enzymes function to catalyse the reduction of molecular oxygen to superoxide and various other reactive oxygen species (ROS). They are subunits of the NADPH oxidase complex.

Enzymes

Click here for help

DUOX1 (dual oxidase 1) Show summary » More detailed page go icon to follow link

DUOX2 (dual oxidase 2) Show summary » More detailed page go icon to follow link

NOX1 (NADPH oxidase 1) Show summary » More detailed page go icon to follow link

NOX2 (cytochrome b-245 beta chain) Show summary » More detailed page go icon to follow link

NOX3 (NADPH oxidase 3) Show summary » More detailed page go icon to follow link

NOX4 (NADPH oxidase 4) Show summary » More detailed page go icon to follow link

NOX5 (NADPH oxidase 5) Show summary » More detailed page go icon to follow link

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.