Pyruvate kinases (EC 2.7.1.40)

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Kinases (EC 2.7.x.x)
Pyruvate kinases (EC 2.7.1.40)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

pyruvate kinase M1/2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3006

Nomenclature

pyruvate kinase M1/2

Previous and unofficial names

pyruvate kinase | OIP3 | PK3 | PKM2 | pyruvate kinase, muscle | THBP1

Genes

PKM (Hs), Pkm (Mm), Pkm (Rn)

Ensembl ID

ENSG00000067225 (Hs), ENSMUSG00000032294 (Mm), ENSRNOG00000011329 (Rn)

UniProtKB AC

P14618 (Hs), P52480 (Mm), P11980 (Rn)

EC number

2.7.1.40
ATP + pyruvate <=> ADP + phosphoenolpyruvate

pyruvate kinase L/R Show summary »« Hide summary

Target Id

3007

Nomenclature

pyruvate kinase L/R

Genes

PKLR (Hs), Pklr (Mm), Pklr (Rn)

Ensembl ID

ENSG00000143627 (Hs), ENSMUSG00000041237 (Mm), ENSRNOG00000020420 (Rn)

UniProtKB AC

P30613 (Hs), P12928 (Rn)

EC number

2.7.1.40
ATP + pyruvate <=> ADP + phosphoenolpyruvate

Allosteric modulators

etavopivat (Positive) pEC₅₀ 6.9 [2]

mitapivat (Positive) [1]

Comment

The protein products of the PKLR gene are isozymes that catalyse the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. This activity is the rate-limiting step of glycolysis.

References

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How to cite this family page

Database page citation:

Pyruvate kinases (EC 2.7.1.40). Accessed on 17/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=994.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.