Antimalarial ligands | Ligand families | IUPHAR/BPS Guide to PHARMACOLOGY

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Antimalarial ligands

Antimalarial ligands

Overview

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This family contains agents that are used for the prevention and/or treatment of malaria infection. It includes approved drugs, clinical candidates and investigational compounds.

Ligands

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ACT-451840 Show summary »« Hide summary More detailed page

AIM-1290 Show summary »« Hide summary More detailed page

albitiazolium Show summary »« Hide summary More detailed page

altiratinib Show summary »« Hide summary More detailed page

amodiaquine Show summary »« Hide summary More detailed page

AN3661 Show summary »« Hide summary More detailed page

AN13762 Show summary »« Hide summary More detailed page

analog 18 [PMID: 28696697] Show summary »« Hide summary More detailed page

apicidin Show summary »« Hide summary More detailed page

Apta-1 Show summary »« Hide summary More detailed page

AQ-13 Show summary »« Hide summary More detailed page

artefenomel Show summary »« Hide summary More detailed page

arteflene Show summary »« Hide summary More detailed page

artemether Show summary »« Hide summary More detailed page

artemisinin Show summary »« Hide summary More detailed page

artemotil Show summary »« Hide summary More detailed page

artenimol Show summary »« Hide summary More detailed page

artesunate Show summary »« Hide summary More detailed page

atovaquone Show summary »« Hide summary More detailed page

azithromycin Show summary »« Hide summary More detailed page

BCH070 Show summary »« Hide summary More detailed page

boromycin Show summary »« Hide summary More detailed page

borrelidin Show summary »« Hide summary More detailed page

bortezomib Show summary »« Hide summary More detailed page

BRD3444 Show summary »« Hide summary More detailed page

BRD7929 Show summary »« Hide summary More detailed page

BRD9185 Show summary »« Hide summary More detailed page

brilacidin Show summary »« Hide summary More detailed page

bulaquine Show summary »« Hide summary More detailed page

CDRI-97/78 Show summary »« Hide summary More detailed page

chloroquine Show summary »« Hide summary More detailed page

chlorotonil A Show summary »« Hide summary More detailed page

CHMFL-PI4K-127 Show summary »« Hide summary More detailed page

cipargamin Show summary »« Hide summary More detailed page

CIS43 Show summary »« Hide summary More detailed page

CJ-15,801 Show summary »« Hide summary More detailed page

cladosporin Show summary »« Hide summary More detailed page

clindamycin Show summary »« Hide summary More detailed page

compound 1 [PMID: 33929818] Show summary »« Hide summary More detailed page

compound 1a [WO2021204952A1] Show summary »« Hide summary More detailed page

compound 1u [PMID: 30245402] Show summary »« Hide summary More detailed page

compound 2 [PMID: 33085774] Show summary »« Hide summary More detailed page

compound 2h [PMID: 30664827] Show summary »« Hide summary More detailed page

compound 3 [PMID: 32258933] Show summary »« Hide summary More detailed page

compound 3j [PMID: 33975947] Show summary »« Hide summary More detailed page

compound 4 [WO2022008639A1] Show summary »« Hide summary More detailed page

compound 5 [PMID: 30894487] Show summary »« Hide summary More detailed page

compound 11c [PMID: 30613327] Show summary »« Hide summary More detailed page

compound 14a [WO2021155612A1] Show summary »« Hide summary More detailed page

compound 24 [PMID: 32959656] Show summary »« Hide summary More detailed page

compound 27 [PMID: 32945666] Show summary »« Hide summary More detailed page

compound 28 [PMID: 31188540] Show summary »« Hide summary More detailed page

compound 34c [PMID: 24641010] Show summary »« Hide summary More detailed page

compound 49c [PMID: 29074775] Show summary »« Hide summary More detailed page

compound 55 [PMID: 29889526] Show summary »« Hide summary More detailed page

compound VII [WO2021149692A1] Show summary »« Hide summary More detailed page

cycloguanil Show summary »« Hide summary More detailed page

dapsone Show summary »« Hide summary More detailed page

DDD85646 Show summary »« Hide summary More detailed page

doxycycline Show summary »« Hide summary More detailed page

DSM265 Show summary »« Hide summary More detailed page

DSM421 Show summary »« Hide summary More detailed page

DSM502 Show summary »« Hide summary More detailed page

DSM705 Show summary »« Hide summary More detailed page

E209 Show summary »« Hide summary More detailed page

ELQ-300 Show summary »« Hide summary More detailed page

ferroquine Show summary »« Hide summary More detailed page

FNDR-20123 Show summary »« Hide summary More detailed page

forodesine Show summary »« Hide summary More detailed page

fosmidomycin Show summary »« Hide summary More detailed page

ganaplacide Show summary »« Hide summary More detailed page

GSK030 Show summary »« Hide summary More detailed page

GSK369796 Show summary »« Hide summary More detailed page

GSK484 Show summary »« Hide summary More detailed page

halofantrine Show summary »« Hide summary More detailed page

halofuginone Show summary »« Hide summary More detailed page

HTI-1 Show summary »« Hide summary More detailed page

hydroxychloroquine Show summary »« Hide summary More detailed page

IMP-1002 Show summary »« Hide summary More detailed page

indolmycin Show summary »« Hide summary More detailed page

INE963 Show summary »« Hide summary More detailed page

IWY357 Show summary »« Hide summary More detailed page

JPC-3210 Show summary »« Hide summary More detailed page

JX35 Show summary »« Hide summary More detailed page

JX21108 Show summary »« Hide summary More detailed page

KDU691 Show summary »« Hide summary More detailed page

KH7 Show summary »« Hide summary More detailed page

L-45 Show summary »« Hide summary More detailed page

lumefantrine Show summary »« Hide summary More detailed page

luteolin Show summary »« Hide summary More detailed page

Lys01 Show summary »« Hide summary More detailed page

M5717 Show summary »« Hide summary More detailed page

mefloquine Show summary »« Hide summary More detailed page

mepacrine Show summary »« Hide summary More detailed page

meplazumab Show summary »« Hide summary More detailed page

methnaridine Show summary »« Hide summary More detailed page

MK-4815 Show summary »« Hide summary More detailed page

ML10 Show summary »« Hide summary More detailed page

ML324 Show summary »« Hide summary More detailed page

MMV008138 Show summary »« Hide summary More detailed page

MMV009108 Show summary »« Hide summary More detailed page

MMV019313 Show summary »« Hide summary More detailed page

MMV024101 Show summary »« Hide summary More detailed page

MMV030084 Show summary »« Hide summary More detailed page

MMV048 Show summary »« Hide summary More detailed page

MMV1803022 Show summary »« Hide summary More detailed page

MMV367 Show summary »« Hide summary More detailed page

MMV688533 Show summary »« Hide summary More detailed page

MMV689258 Show summary »« Hide summary More detailed page

MMV693183 Show summary »« Hide summary More detailed page

MMV897698 Show summary »« Hide summary More detailed page

mupirocin Show summary »« Hide summary More detailed page

naphthoquine Show summary »« Hide summary More detailed page

NCATS-SM3710 Show summary »« Hide summary More detailed page

NPC1161B Show summary »« Hide summary More detailed page

OSM-S-38 Show summary »« Hide summary More detailed page

P218 Show summary »« Hide summary More detailed page

PA21A092 Show summary »« Hide summary More detailed page

panobinostat Show summary »« Hide summary More detailed page

piperaquine Show summary »« Hide summary More detailed page

primaquine Show summary »« Hide summary More detailed page

proguanil Show summary »« Hide summary More detailed page

pyrimethamine Show summary »« Hide summary More detailed page

pyronaridine Show summary »« Hide summary More detailed page

quinidine Show summary »« Hide summary More detailed page

quinine Show summary »« Hide summary More detailed page

quisinostat Show summary »« Hide summary More detailed page

sapanisertib Show summary »« Hide summary More detailed page

SC83288 Show summary »« Hide summary More detailed page

tebuquine Show summary »« Hide summary More detailed page

SGC-CBP30 Show summary »« Hide summary More detailed page

(+)-SJ733 Show summary »« Hide summary More detailed page

SQ-109 Show summary »« Hide summary More detailed page

sulfadoxine Show summary »« Hide summary More detailed page

sulfalene Show summary »« Hide summary More detailed page

sutidiazine Show summary »« Hide summary More detailed page

tafenoquine Show summary »« Hide summary More detailed page

TCMDC-125163 Show summary »« Hide summary More detailed page

TCMDC-135051 Show summary »« Hide summary More detailed page

UCT943 Show summary »« Hide summary More detailed page

WEHI-842 Show summary »« Hide summary More detailed page

WLL-vs Show summary »« Hide summary More detailed page

WM382 Show summary »« Hide summary More detailed page

Further reading

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* Key recommended reading is highlighted with an asterisk

Burrows JN, Duparc S, Gutteridge WE, Hooft van Huijsduijnen R, Kaszubska W, Macintyre F, Mazzuri S, Möhrle JJ, Wells TNC. (2017) New developments in anti-malarial target candidate and product profiles. Malar J, 16 (1): 26. [PMID:28086874]

Campo B, Vandal O, Wesche DL, Burrows JN. (2015) Killing the hypnozoite - drug discovery approaches to prevent relapse in Plasmodium vivax. Pathog Glob Health, 109 (3): 107-22. [PMID:25891812]

Hooft van Huijsduijnen R, Wells TN. (2018) The antimalarial pipeline. Curr Opin Pharmacol, 42: 1-6. [PMID:29860174]

Okombo J, Chibale K. (2018) Recent updates in the discovery and development of novel antimalarial drug candidates. Medchemcomm, 9 (3): 437-453. [PMID:30108934]

* Phillips MA, Burrows JN, Manyando C, van Huijsduijnen RH, Van Voorhis WC, Wells TNC. (2017) Malaria. Nat Rev Dis Primers, 3: 17050. [PMID:28770814]

* Tse EG, Korsik M, Todd MH. (2019) The past, present and future of anti-malarial medicines. Malar J, 18 (1): 93. [PMID:30902052]

* Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A et al.. (2016) Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog, 12 (7): e1005763. [PMID:27467575]

* Wells TN, Hooft van Huijsduijnen R, Van Voorhis WC. (2015) Malaria medicines: a glass half full?. Nat Rev Drug Discov, 14 (6): 424-42. [PMID:26000721]

Wells TN, Willis P, Burrows JN, Hooft van Huijsduijnen R. (2016) Open data in drug discovery and development: lessons from malaria. Nat Rev Drug Discov, 15 (10): 661-2. [PMID:27516171]

How to cite this family page

Database page citation:

Antimalarial ligands. Accessed on 16/08/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=999.