DSM421 [Ligand Id: 10020] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| dihydroorotate dehydrogenase (quinone) in Human [GtoPdb: 2604] [UniProtKB: Q02127] | ||||||||
| GtoPdb | Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. | - | 4 | pIC50 | >100000 | nM | IC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| dihydroorotate dehydrogenase (quinone) in Mouse [GtoPdb: 2604] [UniProtKB: O35435] | ||||||||
| GtoPdb | Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. | - | 4 | pIC50 | >100000 | nM | IC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| dihydroorotate dehydrogenase (quinone) in Rat [GtoPdb: 2604] [UniProtKB: Q63707] | ||||||||
| GtoPdb | Steady-state kinetic analysis performed to measure recombinant enzyme inhibition. | - | 4 | pIC50 | >100000 | nM | IC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis of recombinant enzyme inhibition. | - | 7.28 | pIC50 | 53 | nM | IC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium vivax [GtoPdb: 2949] | ||||||||
| GtoPdb | Steady-state kinetic analysis of recombinant enzyme inhibition. | - | 7.03 | pIC50 | 94 | nM | IC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| GtoPdb | Blood-stage: schizont maturation assay using P. vivax field isolates. | - | 6.74 | pEC50 | 180 | nM | EC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| Plasmodium falciparum dihydroorotate dehydrogenase in Plasmodium falciparum 3D7 [GtoPdb: 2949] [UniProtKB: Q08210] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.37 | pEC50 | 43 | nM | EC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
| GtoPdb | Parasite growth inhibition assay | - | 7.85 | pEC50 | 14 | nM | EC50 | ACS Infect Dis (2016) 2: 945-957 [PMID:27641613] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
