AN3661 [Ligand Id: 10084] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1643740 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against Plasmodium falciparum Ugandan field isolates after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.19 | pIC50 | 64 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum Dd2 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum HB3 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum FCR-3 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum TM90C2B after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 179: 791-804 [PMID:31288128] |
| ChEMBL | Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction of parasitemia after 48 hrs by flow cytometry | F | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 644-651 [PMID:21195617] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum FCR3 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.52 | pIC50 | 30 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum K1 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.7 | pIC50 | 20 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum 3D7 [GtoPdb: 3076] [UniProtKB: Q8IL83] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.28 | pIC50 | 52 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum Dd2 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.41 | pIC50 | 39 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
| Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3 in Plasmodium falciparum HB3 [GtoPdb: 3076] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.25 | pIC50 | 56 | nM | IC50 | Nat Commun (2017) 8: 14574 [PMID:28262680] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
