RO3306 [Ligand Id: 10095] activity data from GtoPdb

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  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 cyclin dependent kinase 1 Human
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  • cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 cyclin dependent kinase 2 Human
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  • cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 cyclin dependent kinase 5 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb In vitro inhibition of human CDK1/cyclin B. - 7.33 pIC50 47 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
cyclin dependent kinase 2 in Human [GtoPdb: 1973] [UniProtKB: P24941]
GtoPdb In vitro inhibition of human CDK2/cyclin A. - 6.6 pIC50 253 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
GtoPdb In vitro inhibition of human CDK2/cyclin E. - 6.73 pIC50 186 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]
cyclin dependent kinase 5 in Human [GtoPdb: 1977] [UniProtKB: Q00535]
GtoPdb In vitro inhibition of human CDK5/p25. - 5.61 pIC50 2480 nM IC50 J Med Chem (2018) 61: 9105-9120 [PMID:30234987]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.