SLC-0111 [Ligand Id: 10149] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1615281 (4-{[(4'-Fluorophenyl)Carbamoyl]Amino}Benzenesulfonamide)
  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
1 CHEMBL1615281_lig_chart_1 Carbonic anhydrase I Human
There should be some charts here, you may need to enable JavaScript!
  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
2 CHEMBL1615281_lig_chart_2 Carbonic anhydrase II Human
There should be some charts here, you may need to enable JavaScript!
  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
  • This target only has 1 pki data point
3 CHEMBL1615281_lig_chart_3 Carbonic anhydrase IV Human
There should be some charts here, you may need to enable JavaScript!
  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
4 CHEMBL1615281_lig_chart_4 Carbonic anhydrase IX Human
There should be some charts here, you may need to enable JavaScript!
  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
  • This target only has 1 pki data point
5 CHEMBL1615281_lig_chart_5 Carbonic anhydrase VII Human
There should be some charts here, you may need to enable JavaScript!
  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
6 CHEMBL1615281_lig_chart_6 Carbonic anhydrase XII Human
There should be some charts here, you may need to enable JavaScript!
  • PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
  • This target only has 1 pki data point
7 CHEMBL1615281_lig_chart_7 PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Mycobacterium tuberculosis
There should be some charts here, you may need to enable JavaScript!
  • Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
  • This target only has 1 pki data point
8 CHEMBL1615281_lig_chart_8 Uncharacterized protein Rv1284/MT1322 Mycobacterium tuberculosis
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
GtoPdb - - 5.29 pKi 5080 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3 [PMID:26233435]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay B 5.29 pKi 5080 nM Ki J. Med. Chem. (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method B 5.29 pKi 5080 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL Inhibition of human carbonic anhydrase 1 for 15 mins by stopped flow CO2 hydration assay B 5.29 pKi 5080 nM Ki Bioorg. Med. Chem. (2016) 24: 976-981 [PMID:26810836]
ChEMBL Inhibition of human recombinant CA1 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 5.29 pKi 5080 nM Ki Bioorg. Med. Chem. (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 5.29 pKi 5080 nM Ki Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL Inhibition of recombinant human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 5.29 pKi 5080 nM Ki Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 5.29 pKi 5080 nM Ki ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL Inhibition of human CA1 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay B 5.29 pKi 5080 nM Ki J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human CA2 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay B 6.02 pKi 960 nM Ki J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL Inhibition of human recombinant CA2 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 6.02 pKi 960 nM Ki Bioorg. Med. Chem. (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 6.02 pKi 960 nM Ki Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 6.02 pKi 960 nM Ki ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method B 6.02 pKi 960 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL Inhibition of human carbonic anhydrase 2 for 15 mins by stopped flow CO2 hydration assay B 6.02 pKi 960 nM Ki Bioorg. Med. Chem. (2016) 24: 976-981 [PMID:26810836]
ChEMBL Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay B 7.02 pKi 96 nM Ki J. Med. Chem. (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL Inhibition of recombinant human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 7.02 pKi 96 nM Ki Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 7.02 pKi 96 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 102-105 [PMID:21145236]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of recombinant human carbonic anhydrase 4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 6.54 pKi 286 nM Ki ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay B 7.35 pKi 45.1 nM Ki J. Med. Chem. (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay B 7.35 pKi 45.1 nM Ki Eur. J. Med. Chem. (2016) 110: 259-266 [PMID:26840366]
ChEMBL Inhibition of human CA9 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay B 7.35 pKi 45.1 nM Ki J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
ChEMBL Inhibition of recombinant human carbonic anhydrase 9 catalytic domain preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 7.35 pKi 45 nM Ki ACS Med Chem Lett (2017) 8: 963-968 [PMID:28947945]
ChEMBL Inhibition of human recombinant CA9 preincubated for 15 mins prior to testing by stopped flow CO2 hydrase assay B 7.35 pKi 45 nM Ki Bioorg. Med. Chem. (2016) 24: 3043-3051 [PMID:27234893]
ChEMBL Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 7.35 pKi 45 nM Ki Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL Inhibition of recombinant human carbonic anhydrase-9 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 7.35 pKi 45 nM Ki Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
ChEMBL Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration method B 7.35 pKi 45 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL Inhibition of human carbonic anhydrase 9 for 15 mins by stopped flow CO2 hydration assay B 7.35 pKi 45 nM Ki Bioorg. Med. Chem. (2016) 24: 976-981 [PMID:26810836]
GtoPdb - - 7.35 pKi 45 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3 [PMID:26233435]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of recombinant human carbonic anhydrase-7 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay B 5.07 pKi 8550 nM Ki Bioorg Med Chem (2017) 25: 3567-3573 [PMID:28522267]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay B 8.35 pKi 4.5 nM Ki J. Med. Chem. (2011) 54: 1896-1902 [PMID:21361354]
ChEMBL Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration method B 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3853 [PMID:26233435]
ChEMBL Inhibition of human carbonic anhydrase 12 for 15 mins by stopped flow CO2 hydration assay B 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. (2016) 24: 976-981 [PMID:26810836]
ChEMBL Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow carbon dioxide hydrase assay B 8.35 pKi 4.5 nM Ki Eur. J. Med. Chem. (2016) 110: 259-266 [PMID:26840366]
ChEMBL Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay B 8.35 pKi 4.5 nM Ki Bioorg Med Chem (2017) 25: 2569-2576 [PMID:28347633]
ChEMBL Inhibition of human CA12 assessed as enzyme inhibitor complex formation preincubated for 15 mins and measured for 10 to 100 secs by phenol red dye based stopped-flow CO2 hydrase assay B 8.35 pKi 4.5 nM Ki J Med Chem (2018) 61: 6328-6338 [PMID:29962205]
GtoPdb - - 8.35 pKi 4.5 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 3850-3 [PMID:26233435]
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
ChEMBL Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 7.28 pKi 53 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 102-105 [PMID:21145236]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay B 8.19 pKi 6.4 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 102-105 [PMID:21145236]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]