tamoxifen [Ligand Id: 1016] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL83 (Nolvadex, ICI-46474, ICI-47699, Tamoxifen, Soltamox)
  • 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
  • This target only has 1 pki data point
  • 8.3
1 CHEMBL83_lig_chart_1 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Human
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  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • This target only has 1 pki data point
  • 4.86
2 CHEMBL83_lig_chart_2 Adenosine A1 receptor Human
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
  • This target only has 1 pki data point
  • 5.4
3 CHEMBL83_lig_chart_3 Adenosine A2a receptor Human
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
  • This target only has 1 pki data point
  • 5.68
4 CHEMBL83_lig_chart_4 Adenosine A3 receptor Human
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  • Aldehyde oxidase in Human [ChEMBL: CHEMBL3257] [UniProtKB: Q06278]
  • This target only has 0 pki data point
  • 0
5 CHEMBL83_lig_chart_5 Aldehyde oxidase Human
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  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
  • This target only has 1 pki data point
  • 5.05
6 CHEMBL83_lig_chart_6 Alpha-1a adrenergic receptor Rat
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • This target only has 1 pki data point
  • 5.61
7 CHEMBL83_lig_chart_7 Alpha-1d adrenergic receptor Human
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • This target only has 1 pki data point
  • 6.14
8 CHEMBL83_lig_chart_8 Alpha-2a adrenergic receptor Human
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
  • This target only has 1 pki data point
  • 5.79
9 CHEMBL83_lig_chart_9 Alpha-2b adrenergic receptor Human
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  • Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
  • This target only has 1 pki data point
  • 4.82
10 CHEMBL83_lig_chart_10 Androgen Receptor Rat
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  • Anti-estrogen binding site (AEBS) in Human [ChEMBL: CHEMBL612409] [UniProtKB: Q15125Q9UBM7]
  • This target only has 0 pki data point
  • 0
11 CHEMBL83_lig_chart_11 Anti-estrogen binding site (AEBS) Human
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  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
  • 5
12 CHEMBL83_lig_chart_12 Beta-1 adrenergic receptor Human
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • This target only has 1 pki data point
  • 5.24
13 CHEMBL83_lig_chart_13 Beta-3 adrenergic receptor Human
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  • ABCB11/Bile salt export pump in Human [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342]
  • This target only has 0 pki data point
  • 0
14 CHEMBL83_lig_chart_14 Bile salt export pump Human
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  • B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
  • This target only has 1 pki data point
  • 4.92
15 CHEMBL83_lig_chart_15 Bradykinin B2 receptor Human
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  • C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
  • This target only has 1 pki data point
  • 5.82
16 CHEMBL83_lig_chart_16 C-8 sterol isomerase Saccharomyces cerevisiae S288c
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  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • This target only has 0 pki data point
  • 0
17 CHEMBL83_lig_chart_17 Cyclooxygenase-1 Human
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  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
  • This target only has 1 pki data point
  • 5.33
18 CHEMBL83_lig_chart_18 Delta opioid receptor Human
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  • D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
  • This target only has 1 pki data point
  • 5.37
19 CHEMBL83_lig_chart_19 Dopamine D1 receptor Human
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • This target only has 1 pki data point
  • 5.33
20 CHEMBL83_lig_chart_20 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 6.44
21 CHEMBL83_lig_chart_21 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
  • 5.41
22 CHEMBL83_lig_chart_22 Dopamine D4 receptor Human
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  • DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
  • This target only has 1 pki data point
  • 5.84
23 CHEMBL83_lig_chart_23 Dopamine transporter Human
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  • Emopamil-binding protein-like in Human [ChEMBL: CHEMBL2311238] [UniProtKB: Q9BY08]
  • This target only has 1 pki data point
  • 8.55
24 CHEMBL83_lig_chart_24 Emopamil-binding protein-like Human
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
  • This target only has 0 pki data point
  • 0
25 CHEMBL83_lig_chart_25 Epidermal growth factor receptor erbB1 Human
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  • Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
  • 7.8
26 CHEMBL83_lig_chart_26 Estrogen receptor alpha Human
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  • Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
  • 7.17
27 CHEMBL83_lig_chart_27 Estrogen receptor beta Human
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  • Estrogen-related receptor-α/Estrogen-related receptor alpha in Human [ChEMBL: CHEMBL3429] [GtoPdb: 622] [UniProtKB: P11474]
  • This target only has 0 pki data point
  • 0
28 CHEMBL83_lig_chart_28 Estrogen-related receptor alpha Human
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  • Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
  • This target only has 1 pki data point
  • 6.1
29 CHEMBL83_lig_chart_29 HERG Human
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  • H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
  • This target only has 1 pki data point
  • 5.03
30 CHEMBL83_lig_chart_30 Histamine H2 receptor Human
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  • κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
  • This target only has 1 pki data point
  • 5.2
31 CHEMBL83_lig_chart_31 Kappa opioid receptor Human
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  • MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
  • This target only has 1 pki data point
  • 4.76
32 CHEMBL83_lig_chart_32 Melanocortin receptor 3 Human
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  • MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
  • This target only has 1 pki data point
  • 4.53
33 CHEMBL83_lig_chart_33 Melanocortin receptor 4 Human
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  • MC5 receptor/Melanocortin receptor 5 in Human [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032]
  • This target only has 1 pki data point
  • 4.6
34 CHEMBL83_lig_chart_34 Melanocortin receptor 5 Human
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  • μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
  • This target only has 1 pki data point
  • 5.15
35 CHEMBL83_lig_chart_35 Mu opioid receptor Human
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 1 pki data point
  • 6.17
36 CHEMBL83_lig_chart_36 Muscarinic acetylcholine receptor M1 Human
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  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 1 pki data point
  • 5.56
37 CHEMBL83_lig_chart_37 Muscarinic acetylcholine receptor M2 Human
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  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 1 pki data point
  • 6.2
38 CHEMBL83_lig_chart_38 Muscarinic acetylcholine receptor M3 Human
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  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 6.17
39 CHEMBL83_lig_chart_39 Muscarinic acetylcholine receptor M4 Human
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  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
  • This target only has 1 pki data point
  • 5.73
40 CHEMBL83_lig_chart_40 Muscarinic acetylcholine receptor M5 Human
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  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
  • This target only has 1 pki data point
  • 5.07
41 CHEMBL83_lig_chart_41 Neurokinin 1 receptor Human
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  • NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
  • This target only has 1 pki data point
  • 5.91
42 CHEMBL83_lig_chart_42 Neurokinin 2 receptor Human
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  • NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
  • This target only has 1 pki data point
  • 5.84
43 CHEMBL83_lig_chart_43 Norepinephrine transporter Human
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  • ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
  • This target only has 1 pki data point
  • 7
44 CHEMBL83_lig_chart_44 P-glycoprotein 1 Human
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  • PLD1/Phospholipase D1 in Rat [ChEMBL: CHEMBL3308939] [GtoPdb: 1433] [UniProtKB: P70496]
  • This target only has 0 pki data point
  • 0
45 CHEMBL83_lig_chart_45 Phospholipase D1 Rat
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  • Progesterone receptor in Human [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
  • Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
  • This target only has 1 pki data point
  • 5.59
46 CHEMBL83_lig_chart_46 Progesterone receptor HumanBovine
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  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
  • This target only has 0 pki data point
  • 0
47 CHEMBL83_lig_chart_47 Receptor protein-tyrosine kinase erbB-2 Human
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  • Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform in Human [ChEMBL: CHEMBL4445] [UniProtKB: Q08209]
  • This target only has 0 pki data point
  • 0
48 CHEMBL83_lig_chart_48 Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • This target only has 1 pki data point
  • 5.16
49 CHEMBL83_lig_chart_49 Serotonin 1a (5-HT1a) receptor Rat
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
  • 5.86
50 CHEMBL83_lig_chart_50 Serotonin 2a (5-HT2a) receptor Human
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
  • 5.88
51 CHEMBL83_lig_chart_51 Serotonin 2b (5-HT2b) receptor Human
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
  • 6.62
52 CHEMBL83_lig_chart_52 Serotonin 2c (5-HT2c) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5.94
53 CHEMBL83_lig_chart_53 Serotonin 6 (5-HT6) receptor Human
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  • SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
  • This target only has 1 pki data point
  • 5.91
54 CHEMBL83_lig_chart_54 Serotonin transporter Human
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  • sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
  • 7.76
55 CHEMBL83_lig_chart_55 Sigma opioid receptor Human
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  • CYP5A1/Thromboxane-A synthase in Human [ChEMBL: CHEMBL1835] [GtoPdb: 1353] [UniProtKB: P24557]
  • This target only has 0 pki data point
  • 0
56 CHEMBL83_lig_chart_56 Thromboxane-A synthase Human
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  • Transcriptional activator protein luxR in Aliivibrio fischeri [ChEMBL: CHEMBL5351] [UniProtKB: P12746]
  • This target only has 0 pki data point
  • 0
57 CHEMBL83_lig_chart_57 Transcriptional activator protein luxR Aliivibrio fischeri
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