ChEMBL ligand: CHEMBL2386284
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
GtoPdb	-	-	6.35	pKi	442	nM	Ki	J Med Chem (2013) 56: 4611-8 [PMID:23731360]
ChEMBL	Inhibition of human recombinant microsomal aromatase using 7-methoxy-4-trifluoromethylcoumarin as substrate by Lineweaver-Burk plot analysis	B	6.35	pKi	442	nM	Ki	J Med Chem (2013) 56: 4611-4618 [PMID:23731360]
ChEMBL	Inhibition of human recombinant microsomal aromatase-mediated 7-methoxy-4-trifluoromethylcoumarin conversion to 7-hydroxytrifluoromethylcoumarin preincubated for 10 mins measured after 30 mins by fluorescence assay	B	5.99	pIC50	1029	nM	IC50	J Med Chem (2013) 56: 4611-4618 [PMID:23731360]
ChEMBL	Inhibition of recombinant human microsomal CYP19 using MFC as substrate measured after 30 mins by fluorometric analysis	B	5.99	pIC50	1029	nM	IC50	Bioorg Med Chem (2016) 24: 5400-5409 [PMID:27647367]
ChEMBL	Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 mins	B	7.52	pIC50	30	nM	IC50	J Med Chem (2016) 59: 5131-5148 [PMID:26689671]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL	Displacement of fluorescent ES2 from human recombinant ERalpha after 2 hrs by fluorimetric analysis	B	7.77	pEC50	17	nM	EC50	J Med Chem (2013) 56: 4611-4618 [PMID:23731360]
ChEMBL	Displacement of fluorescent ES2 from recombinant human ERalpha after 2 hrs in absence of light by fluorometric analysis	B	7.77	pEC50	17	nM	EC50	Bioorg Med Chem (2016) 24: 5400-5409 [PMID:27647367]
GtoPdb	-	-	7.77	pEC50	17	nM	EC50	J Med Chem (2013) 56: 4611-8 [PMID:23731360]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
GtoPdb	-	-	7.56	pEC50	27.5	nM	EC50	J Med Chem (2013) 56: 4611-8 [PMID:23731360]
ChEMBL	Displacement of fluorescent ES2 from human recombinant ERbeta after 2 hrs by fluorimetric analysis	B	7.56	pEC50	27.5	nM	EC50	J Med Chem (2013) 56: 4611-4618 [PMID:23731360]
ChEMBL	Displacement of fluorescent ES2 from recombinant human ERbeta after 2 hrs in absence of light by fluorometric analysis	B	7.56	pEC50	27.5	nM	EC50	Bioorg Med Chem (2016) 24: 5400-5409 [PMID:27647367]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]