ChEMBL ligand: CHEMBL4167748
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against mature gametocytes of Plasmodium falciparum NF54 infected in mouse by standard membrane feeding assay	F	7.39	pIC50	41	nM	IC50	J Med Chem (2018) 61: 8061-8077 [PMID:29771541]
ChEMBL	Antiplasmodial activity against mature gametocytes of Plasmodium falciparum 3D7 infected in mouse	F	8.68	pIC50	2.1	nM	IC50	J Med Chem (2018) 61: 8061-8077 [PMID:29771541]
Plasmodium falciparum cGMP-dependent protein kinase in Plasmodium falciparum 3D7 [GtoPdb: 3013] [UniProtKB: Q8I719]
GtoPdb	microfluidic mobility shift assay	-	9.8	pIC50	0.16	nM	IC50	Nat Commun (2017) 8: 430 [PMID:28874661]
GtoPdb	Parasite growth inhibition assay	-	8.68	pEC50	2.1	nM	EC50	Nat Commun (2017) 8: 430 [PMID:28874661]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]