cladosporin [Ligand Id: 10247] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL448685 (Cladosporin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.1 | pIC50 | 80.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.06 | pIC50 | 87.9 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium yoelii [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite liver stage assay | - | 7.41 | pIC50 | 39.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase/Lysine--tRNA ligase in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3301561] [GtoPdb: 3059] [UniProtKB: Q8IDJ8] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum KRS expressed in Escherichia coli BL21 using tRNA(Lys) as substrate after 45 mins in presence of L-lysine by AMP-GLO assay | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2018) 61: 5664-5678 [PMID:29779382] |
| GtoPdb | Parasite growth inhibition assay | - | 7.34 | pIC50 | 45.4 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum D6 [GtoPdb: 3059] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.14 | pIC50 | 72.1 | nM | IC50 | Cell Host Microbe (2012) 11: 654-63 [PMID:22704625] |
| Lysyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5575] [UniProtKB: Q15046] | ||||||||
| ChEMBL | Inhibition of human recombinant cytoplasmic lysyl-tRNA synthetase | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum D10 | F | 7.05 | pEC50 | 90 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| ChEMBL | Antiplasmodial activity against liver stage of drug-sensitive Plasmodium falciparum 3D7 | F | 7.35 | pEC50 | 45 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 2829-2843 [PMID:23587422] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green-1 staining based assay | F | 7.4 | pEC50 | 40 | nM | EC50 | J Med Chem (2018) 61: 5664-5678 [PMID:29779382] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
