spinorphin [Ligand Id: 1026] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL395493 (spinorphin)
There should be some charts here, you may need to enable JavaScript!
  • FPR1 in Human [GtoPdb: 222] [UniProtKB: P21462]
  • FPR1 in Mouse [GtoPdb: 222] [UniProtKB: P33766]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2X3/P2X purinoceptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2998] [GtoPdb: 480] [UniProtKB: P56373]
ChEMBL Antagonist activity at human recombinant P2X3 receptor expressed in Xenopus oocytes assessed as inhibition of ATP-induced ion current in presence of 20 nM LVVYPWA peptide by two electrode voltage clamping technique F 10.32 pIC50 0.05 nM IC50 J. Med. Chem. (2007) 50: 4543-4547 [PMID:17676725]
GtoPdb - - 11 pIC50 - - -
FPR1 in Human [GtoPdb: 222] [UniProtKB: P21462]
GtoPdb - - 4.3 pIC50 - - - J Immunol (2001) 167: 6609-14 [PMID:11714831];
J Biol Chem (1992) 267: 7637-43 [PMID:1373134]
FPR1 in Mouse [GtoPdb: 222] [UniProtKB: P33766]
GtoPdb - - 3.9 pEC50 - - - J Immunol (2001) 167: 6609-14 [PMID:11714831]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]