ASP7663 [Ligand Id: 10274] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1082283 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in membrane currents | F | 6.08 | pEC50 | 830 | nM | EC50 | J Med Chem (2010) 53: 5085-5107 [PMID:20356305] |
| GtoPdb | Ligand-induced increase in intracellular Ca2+ in HEK293 cells expressing hTRPA1. | - | 6.29 | pEC50 | 510 | nM | EC50 | Eur J Pharmacol (2014) 723: 288-93 [PMID:24291101] |
| TRPA1 in Mouse [GtoPdb: 485] [UniProtKB: Q8BLA8] | ||||||||
| GtoPdb | Ligand-induced increase in intracellular Ca2+ in HEK293 cells expressing mTrpa1. | - | 6.3 | pEC50 | 500 | nM | EC50 | Eur J Pharmacol (2014) 723: 288-93 [PMID:24291101] |
| TRPA1 in Rat [GtoPdb: 485] [UniProtKB: Q6RI86] | ||||||||
| GtoPdb | Ligand-induced increase in intracellular Ca2+ in HEK293 cells expressing rTrpa1. | - | 6.27 | pEC50 | 540 | nM | EC50 | Eur J Pharmacol (2014) 723: 288-93 [PMID:24291101] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
