SANT-2 [Ligand Id: 10331] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL514344
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  • SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226]
ChEMBL Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG F 7.01 pIC50 97.9 nM IC50 Bioorg Med Chem (2009) 17: 4943-4954 [PMID:19541490]
ChEMBL Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay B 7.52 pIC50 30 nM IC50 J Med Chem (2009) 52: 3829-3845 [PMID:19309080]
SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
GtoPdb In Gli-dependent reporter assays in Shh-LIGHT2 cells. - 7.52 pIC50 30 nM IC50 Proc Natl Acad Sci USA (2002) 99: 14071-6 [PMID:12391318]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]