BL-1249 [Ligand Id: 10336] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1417584 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| K2P10.1/Potassium channel subfamily K member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331041] [GtoPdb: 521] [UniProtKB: P57789] | ||||||||
| GtoPdb | - | - | 5.1 | pEC50 | 8000 | nM | EC50 | ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357] |
| ChEMBL | Activation of human TREK2 by thallium flux mobilization assay | B | 5.11 | pEC50 | 7700 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652] |
| K2P18.1/Potassium channel subfamily K member 18 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418] | ||||||||
| ChEMBL | Activation of human TRESK channel relative to control | B | 5.22 | pEC50 | 6000 | nM | EC50 | Bioorg Med Chem Lett (2016) 26: 4919-4924 [PMID:27641472] |
| K2P2.1/Potassium channel subfamily K member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069] | ||||||||
| GtoPdb | - | - | 5.26 | pEC50 | 5500 | nM | EC50 | ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357] |
| ChEMBL | Activation of human TREK1 by thallium flux mobilization assay | B | 5.28 | pEC50 | 5200 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
