BL-1249 [Ligand Id: 10336] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1417584
  • K2P18.1/Potassium channel subfamily K member 18 in Human [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418]
There should be some charts here, you may need to enable JavaScript!
  • K2P2.1 in Human [GtoPdb: 514] [UniProtKB: O95069]
There should be some charts here, you may need to enable JavaScript!
  • K2P10.1 in Human [GtoPdb: 521] [UniProtKB: P57789]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
K2P18.1/Potassium channel subfamily K member 18 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418]
ChEMBL Activation of human TRESK channel relative to control B 5.22 pEC50 6000 nM EC50 Bioorg Med Chem Lett (2016) 26: 4919-4924 [PMID:27641472]
K2P2.1 in Human [GtoPdb: 514] [UniProtKB: O95069]
GtoPdb - - 5.26 pEC50 5500 nM EC50 ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357]
K2P10.1 in Human [GtoPdb: 521] [UniProtKB: P57789]
GtoPdb - - 5.1 pEC50 8000 nM EC50 ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]