GNE-616 [Ligand Id: 10355] activity data from GtoPdb

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  • Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498]
  • This target only has 0 pki data point
1 _lig_chart_1 Nav1.1 Human
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  • Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250]
  • This target only has 0 pki data point
2 _lig_chart_2 Nav1.2 Human
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  • Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46]
  • This target only has 0 pki data point
3 _lig_chart_3 Nav1.3 Human
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  • Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
  • This target only has 0 pki data point
4 _lig_chart_4 Nav1.4 Human
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  • Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
  • This target only has 0 pki data point
5 _lig_chart_5 Nav1.5 Human
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  • Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
  • This target only has 0 pki data point
6 _lig_chart_6 Nav1.6 Human
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  • Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
  • Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562]
  • This target only has 1 pki data point
7 _lig_chart_7 Nav1.7 HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 6 pKd >1000 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 7.92 pKd 12 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 6 pKd >1000 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 6 pKd >1000 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 6 pKd >1000 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 7.54 pKd 29 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 9.42 pKd 0.38 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
GtoPdb Binding affinity for hNav1.7 determined in a radioligand binding assay. - 9.1 pKi 0.79 nM Ki J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]
Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562]
GtoPdb Kd determined in a Dynaflow Manual Patch Clamp experiment. - 7.48 pKd 33 nM Kd J. Med. Chem. (2019) 62: 4091-4109 [PMID:30943032]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.