GNE-616 [Ligand Id: 10355] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.1 in Human [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 6 | pKd | >1000 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.2 in Human [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 7.92 | pKd | 12 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 6 | pKd | >1000 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 6 | pKd | >1000 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.5 in Human [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 6 | pKd | >1000 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.6 in Human [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 7.54 | pKd | 29 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 9.42 | pKd | 0.38 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| GtoPdb | Binding affinity for hNav1.7 determined in a radioligand binding assay. | - | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
| Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562] | ||||||||
| GtoPdb | Kd determined in a Dynaflow Manual Patch Clamp experiment. | - | 7.48 | pKd | 33 | nM | Kd | J Med Chem (2019) 62: 4091-4109 [PMID:30943032] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
