ONO-2333MS [Ligand Id: 10376] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1819077
  • CRF1 receptor/Corticotropin releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
  • CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
  • This target only has 0 pki data point
1 CHEMBL1819077_lig_chart_1 Corticotropin releasing factor receptor 1 HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting B 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. (2011) 19: 5432-5445 [PMID:21865047]
GtoPdb - - 8.4 pIC50 4 nM IC50 Bioorg. Med. Chem. (2011) 19: 5432-45 [PMID:21865047]
ChEMBL Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay F 7.4 pEC50 40 nM EC50 Bioorg. Med. Chem. (2011) 19: 5432-5445 [PMID:21865047]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
ChEMBL Displacement of [125I]CRF from corticotropin-releasing factor receptor 1 in rat brain membranes after 2 hrs by gamma counting B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. (2011) 19: 5432-5445 [PMID:21865047]
ChEMBL Antagonist activity at rat corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay F 7.4 pEC50 40 nM EC50 Bioorg. Med. Chem. (2011) 19: 5432-5445 [PMID:21865047]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]