compound 5 [PMID: 30894487] [Ligand Id: 10398] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3989220
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059]
  • Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum K1 [GtoPdb: 3059]
GtoPdb Parasite growth inhibition assay - 6.29 pEC50 510 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum NF54 [GtoPdb: 3059]
GtoPdb Parasite stage V gametocyte assay - 5 pEC50 9900 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
GtoPdb Parasite gamete formation assay - 6 pEC50 >1000 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
GtoPdb Parasite growth inhibition assay - 6.41 pEC50 390 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium vivax [GtoPdb: 3059]
GtoPdb Parasite liver stage assay - 6.02 pEC50 950 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]
Plasmodium falciparum lysyl-tRNA synthetase in Plasmodium falciparum 3D7 [GtoPdb: 3059] [UniProtKB: Q8IDJ8]
GtoPdb Parasite growth inhibition assay - 6.57 pEC50 270 nM EC50 Proc Natl Acad Sci USA (2019) 116: 7015-7020 [PMID:30894487]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]