PDE4 inhibitor 16 [Ligand Id: 10400] activity data from GtoPdb

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  • phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
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  • phosphodiesterase 10A in Human [GtoPdb: 1310] [UniProtKB: Q9Y233]
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  • phosphodiesterase 6C in Human [GtoPdb: 1314] [UniProtKB: P51160]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphodiesterase 4D in Human [GtoPdb: 1303] [UniProtKB: Q08499]
GtoPdb Inhibition of enzymatic activity of the recombinant human PDE4D catalytic domain in vitro. - 6.62 pIC50 240 nM IC50 J. Med. Chem. (2019) 62: 5579-5593 [PMID:31099559]
phosphodiesterase 10A in Human [GtoPdb: 1310] [UniProtKB: Q9Y233]
GtoPdb Inhibition of enzymatic activity of the recombinant human PDE10A catalytic domain in vitro. - 6.04 pIC50 920 nM IC50 J. Med. Chem. (2019) 62: 5579-5593 [PMID:31099559]
phosphodiesterase 6C in Human [GtoPdb: 1314] [UniProtKB: P51160]
GtoPdb Inhibition of enzymatic activity of the recombinant human PDE6C catalytic domain in vitro. - 5.48 pIC50 3300 nM IC50 J. Med. Chem. (2019) 62: 5579-5593 [PMID:31099559]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.