ChEMBL ligand: CHEMBL2334045
Plasmodium berghei [ChEMBL: CHEMBL612653] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL	Antimalarial activity against GFP-transfected Plasmodium berghei ANKA in mouse blood assessed as inhibition of schizont maturation compound incubated for 16 hrs followed by 8 hrs of [3H]hypoxanthine incorporation	F	6.3	pIC50	>500	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 24 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax	F	6.3	pIC50	>500	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352]
ChEMBL	Antimalarial activity against Plasmodium falciparum incubated for 24 hrs	F	6.3	pIC50	>500	nM	IC50	J Med Chem (2020) 63: 4445-4467 [PMID:31913032]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 50 % serum	F	9.22	pIC50	<0.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in RBC after 72 hrs by [3H]hypoxanthine incorporation assay in presence of 0.5 % albumax	F	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-662 [PMID:23260352]
ChEMBL	Antimalarial activity against Plasmodium falciparum incubated for 72 hrs	F	9.22	pIC50	0.6	nM	IC50	J Med Chem (2020) 63: 4445-4467 [PMID:31913032]
Plasmodium falciparum plasmepsin X in Plasmodium falciparum NF54 [GtoPdb: 3071]
GtoPdb	Parasite growth inhibition assay	-	6.3	pIC50	>500	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352]
GtoPdb	Parasite growth inhibition assay	-	9.22	pIC50	0.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 658-62 [PMID:23260352]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]