BMS-986165 [Ligand Id: 10432] activity data from GtoPdb

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  • bone morphogenetic protein receptor type 2 in Human [GtoPdb: 1794] [UniProtKB: Q13873]
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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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  • tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
bone morphogenetic protein receptor type 2 in Human [GtoPdb: 1794] [UniProtKB: Q13873]
GtoPdb - - 6.71 pIC50 193 nM IC50 J. Med. Chem. (2019) 62: 8973-8995 [PMID:31318208]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb Binding to JAK1 JH2 pseudokinase domain. - 9 pIC50 1 nM IC50 J. Med. Chem. (2019) 62: 8973-8995 [PMID:31318208]
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb Determined in a Morrison titration by varying the concentration of the fluorescent probe in the TYK2 JH2 assay. - 10.7 pKi 0.02 nM Ki J. Med. Chem. (2019) 62: 8973-8995 [PMID:31318208]
GtoPdb Binding to TYK2's JH2 pseudokinase domain in a biochemical binding assay. - 9.7 pIC50 0.2 nM IC50 J. Med. Chem. (2019) 62: 8973-8995 [PMID:31318208]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.