compound E22 [PMID: 31298542] [Ligand Id: 10437] activity data from GtoPdb

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  • AKT serine/threonine kinase 1 in Human [GtoPdb: 1479] [UniProtKB: P31749]
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  • AKT serine/threonine kinase 2 in Human [GtoPdb: 1480] [UniProtKB: P31751]
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  • Rho associated coiled-coil containing protein kinase 1 in Human [GtoPdb: 1503] [UniProtKB: Q13464]
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  • ribosomal protein S6 kinase B1 in Human [GtoPdb: 1525] [UniProtKB: P23443]
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  • ribosomal protein S6 kinase A1 in Human [GtoPdb: 1527] [UniProtKB: Q15418]
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  • protein kinase A in Human [GtoPdb: 1694]
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  • AKT serine/threonine kinase 3 in Human [GtoPdb: 2286] [UniProtKB: Q9Y243]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AKT serine/threonine kinase 1 in Human [GtoPdb: 1479] [UniProtKB: P31749]
GtoPdb - - 8.86 pIC50 1.37 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
AKT serine/threonine kinase 2 in Human [GtoPdb: 1480] [UniProtKB: P31751]
GtoPdb - - 8.92 pIC50 1.2 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
Rho associated coiled-coil containing protein kinase 1 in Human [GtoPdb: 1503] [UniProtKB: Q13464]
GtoPdb - - 7.19 pIC50 64 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
ribosomal protein S6 kinase B1 in Human [GtoPdb: 1525] [UniProtKB: P23443]
GtoPdb - - 8.05 pIC50 8.9 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
ribosomal protein S6 kinase A1 in Human [GtoPdb: 1527] [UniProtKB: Q15418]
GtoPdb - - 6.88 pIC50 131 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb - - 9.52 pIC50 0.3 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]
AKT serine/threonine kinase 3 in Human [GtoPdb: 2286] [UniProtKB: Q9Y243]
GtoPdb - - 8.77 pIC50 1.7 nM IC50 J. Med. Chem. (2019) 62: 7264-7288 [PMID:31298542]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.