brepocitinib [Ligand Id: 10459] activity data from GtoPdb

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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
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  • tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 7.77 pIC50 17 nM IC50 J. Med. Chem. (2018) 61: 8597-8612 [PMID:30113844]
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 7.11 pIC50 77 nM IC50 J. Med. Chem. (2018) 61: 8597-8612 [PMID:30113844]
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 5.19 pIC50 6494 nM IC50 J. Med. Chem. (2018) 61: 8597-8612 [PMID:30113844]
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb - - 7.64 pIC50 23 nM IC50 J. Med. Chem. (2018) 61: 8597-8612 [PMID:30113844]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.