ChEMBL ligand: CHEMBL3764045 (Pamufetinib, Tas-115)
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] There should be some charts here, you may need to enable JavaScript!
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
GtoPdb	-	-	7.41	pKi	39	nM	Ki	Mol Cancer Ther (2013) 12: 2685-96 [PMID:24140932]
ChEMBL	Inhibition of recombinant N-terminal GST-tagged human Met using FLPeptide 2 as substrate after 90 mins by mobility shift assay	B	7.49	pIC50	32	nM	IC50	Eur J Med Chem (2016) 108: 495-504 [PMID:26717201]
ChEMBL	Inhibition of N-terminal GST-tagged human recombinant c-MET (956 to 1390 residues) expressed in Baculovirus infected Sf9 cell expression system by ELISA analysis	B	7.49	pIC50	32	nM	IC50	RSC Med Chem (2024) 15: 2553-2569 [PMID:39026631]
ChEMBL	Inhibition of c-Met (unknown origin) by mobility shift assay	B	7.49	pIC50	32	nM	IC50	Eur J Med Chem (2023) 261: 115796-115796 [PMID:37708796]
platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234]
ChEMBL	Inhibition of wild type human PDGFRalpha transfected with CHO cells by ADP-Glo assay	B	9.09	pIC50	0.81	nM	IC50	Eur J Med Chem (2023) 260: 115762-115762 [PMID:37683364]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL	Inhibition of PDGFRbeta (unknown origin) by DiscoverX KINOMEscan assay	B	8.15	pIC50	7.06	nM	IC50	Eur J Med Chem (2023) 260: 115762-115762 [PMID:37683364]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL	Inhibition of AXL (unknown origin) by FRET assay	B	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2023) 261: 115796-115796 [PMID:37708796]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb	-	-	7.92	pKi	12	nM	Ki	Mol Cancer Ther (2013) 12: 2685-96 [PMID:24140932]
ChEMBL	Inhibition of recombinant N-terminal 6His-tagged VEGFR-2 (unknown origin) using FL-Peptide 22 as substrate after 90 mins by mobility shift assay	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2016) 108: 495-504 [PMID:26717201]
ChEMBL	Inhibition of human recombinant VEGFR2 (805 to 1356 residues) in presence of ATP by ELISA analysis	B	7.52	pIC50	30	nM	IC50	RSC Med Chem (2024) 15: 2553-2569 [PMID:39026631]
ChEMBL	Inhibition of VEGFR-2 (unknown origin) by ELISA method	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2023) 261: 115796-115796 [PMID:37708796]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]