mepenzolic acid [Ligand Id: 10470] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL524004 (Mepenzolate, Mepenzolate bromide free base, Mepenzolate cation, Mepenzolate ion)
  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
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  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
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  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 9.17 pKi 0.68 nM Ki Bioorg Med Chem (2014) 22: 3488-97 [PMID:24844758]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 8.59 pKi 2.6 nM Ki Bioorg Med Chem (2014) 22: 3488-97 [PMID:24844758]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 9.44 pKi 0.36 nM Ki Invest Ophthalmol Vis Sci (2018) 59: 2778-2791 [PMID:29860464]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]