compound 12b [PMID: 31465220] [Ligand Id: 10489] activity data from GtoPdb

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  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
  • This target only has 0 pki data point
1 _lig_chart_1 mechanistic target of rapamycin kinase Human
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  • phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [GtoPdb: 2152] [UniProtKB: Q8NEB9]
  • This target only has 0 pki data point
2 _lig_chart_2 phosphatidylinositol 3-kinase catalytic subunit type 3 Human
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
  • This target only has 0 pki data point
3 _lig_chart_3 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Human
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
  • This target only has 0 pki data point
4 _lig_chart_4 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb - - 7.85 pKd 14 nM Kd J. Med. Chem. (2019) 62: 8609-8630 [PMID:31465220]
phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [GtoPdb: 2152] [UniProtKB: Q8NEB9]
GtoPdb - - 5.49 pKd 3200 nM Kd J. Med. Chem. (2019) 62: 8609-8630 [PMID:31465220]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 5.8 pKd 1600 nM Kd J. Med. Chem. (2019) 62: 8609-8630 [PMID:31465220]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 5.12 pKd 7500 nM Kd J. Med. Chem. (2019) 62: 8609-8630 [PMID:31465220]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.