SWE101 [Ligand Id: 10494] activity data from GtoPdb

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  • COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
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  • COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
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  • epoxide hydrolase 2 in Human [GtoPdb: 2970] [UniProtKB: P34913]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 5.92 pIC50 1200 nM IC50 J. Med. Chem. (2019) 62: 8443-8460 [PMID:31436984]
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 6.38 pIC50 420 nM IC50 J. Med. Chem. (2019) 62: 8443-8460 [PMID:31436984]
epoxide hydrolase 2 in Human [GtoPdb: 2970] [UniProtKB: P34913]
GtoPdb Binding affinity for the N-terminal domain of sEH by isothermal titration calorimetry. - 6.52 pKd 300 nM Kd J. Med. Chem. (2019) 62: 8443-8460 [PMID:31436984]
GtoPdb Inhibition of sEH's phosphatase activity. - 7.24 pIC50 58 nM IC50 J. Med. Chem. (2019) 62: 8443-8460 [PMID:31436984]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.