medica 16 [Ligand Id: 1053] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL63829 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ATP-citrate synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2745] [UniProtKB: P16638] | ||||||||
| ChEMBL | Competitive inhibition of rat liver ACLY using citrate as substrate by spectrophotometric analysis | B | 4.8 | pKi | 16000 | nM | Ki | J Med Chem (2011) 54: 5615-5638 [PMID:21726077] |
| ChEMBL | Inhibition of rat liver ACLY | B | 4.8 | pKi | 16000 | nM | Ki | Eur J Med Chem (2018) 157: 1276-1291 [PMID:30195238] |
| ChEMBL | Inhibition of rat ACLY | B | 4.8 | pKi | 16000 | nM | Ki | J Med Chem (2023) 66: 9229-9250 [PMID:37428122] |
| ChEMBL | Competitive inhibition of rat liver ACLY using CoA as substrate by spectrophotometric analysis | B | 5.52 | pKi | 3000 | nM | Ki | J Med Chem (2011) 54: 5615-5638 [PMID:21726077] |
| FFA1 receptor/Free fatty acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4422] [GtoPdb: 225] [UniProtKB: O14842] | ||||||||
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | Biochem Biophys Res Commun (2003) 301: 406-10 [PMID:12565875] |
| ChEMBL | Agonist activity at human GPR40 expressed in HEK293 cells by Fluo4-AM dye based intracellular calcium flux assay | F | 5.91 | pEC50 | 1220 | nM | EC50 | Eur J Med Chem (2024) 264: 115990-115990 [PMID:38039791] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
