oleic acid [Ligand Id: 1054] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL8659 (18:1(N-9), Oleic Acid, FEMA NO. 2815, NSC-9856)
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • This target only has 1 pki data point
1 CHEMBL8659_lig_chart_1 Anandamide amidohydrolase Human
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  • coagulation factor VII/Coagulation factor VII/tissue factor in Human [ChEMBL: CHEMBL2095194] [GtoPdb: 2363] [UniProtKB: P08709P13726]
  • This target only has 0 pki data point
2 CHEMBL8659_lig_chart_2 Coagulation factor VII/tissue factor Human
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  • CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
  • This target only has 0 pki data point
3 CHEMBL8659_lig_chart_3 Cytochrome P450 19A1 Human
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  • DNA topoisomerase I in Human [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
  • This target only has 0 pki data point
4 CHEMBL8659_lig_chart_4 DNA topoisomerase I Human
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  • fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
5 CHEMBL8659_lig_chart_5 Fatty acid binding protein adipocyte Human
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  • fatty acid binding protein 5/Fatty acid binding protein epidermal in Human [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469]
  • This target only has 1 pki data point
6 CHEMBL8659_lig_chart_6 Fatty acid binding protein epidermal Human
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  • fatty acid binding protein 1/Fatty acid-binding protein, liver in Human [ChEMBL: CHEMBL5421] [GtoPdb: 2531] [UniProtKB: P07148]
  • fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
7 CHEMBL8659_lig_chart_7 Fatty acid-binding protein, liver HumanRat
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  • Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
  • This target only has 0 pki data point
8 CHEMBL8659_lig_chart_8 Peroxisome proliferator-activated receptor alpha Human
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  • Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
  • This target only has 0 pki data point
9 CHEMBL8659_lig_chart_9 Peroxisome proliferator-activated receptor delta Human
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  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
  • This target only has 0 pki data point
10 CHEMBL8659_lig_chart_10 Peroxisome proliferator-activated receptor gamma Human
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  • Seed lipoxygenase-1 in Glycine max [ChEMBL: CHEMBL4586] [UniProtKB: P08170]
  • This target only has 1 pki data point
11 CHEMBL8659_lig_chart_11 Seed lipoxygenase-1 Glycine max
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  • Telomerase reverse transcriptase in Human [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
  • This target only has 0 pki data point
12 CHEMBL8659_lig_chart_12 Telomerase reverse transcriptase Human
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  • TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
  • This target only has 0 pki data point
13 CHEMBL8659_lig_chart_13 Transient receptor potential cation channel subfamily V member 2 Rat
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  • FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3]
  • This target only has 0 pki data point
14 CHEMBL8659_lig_chart_14 FFA4 receptor Human
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  • FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842]
  • This target only has 0 pki data point
15 CHEMBL8659_lig_chart_15 FFA1 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL Inhibition of FAAH B 5.22 pKi 6000 nM Ki J. Med. Chem. (2008) 51: 7327-7343 [PMID:18983142]
coagulation factor VII/Coagulation factor VII/tissue factor in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095194] [GtoPdb: 2363] [UniProtKB: P08709P13726]
ChEMBL Inhibition of amidolytic activity of human tissue factor/human factor 7a B 4.1 pIC50 80000 nM IC50 J. Nat. Prod. (1998) 61: 1352-1355 [PMID:9834151]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL Inhibition of aromatase in human placental microsomes by radiometric method B 4.49 pIC50 32700 nM IC50 J. Nat. Prod. (2006) 69: 700-703 [PMID:16643058]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of DNA topoisomerase 1 B 4.51 pIC50 31000 nM IC50 J. Nat. Prod. (2002) 65: 1715-1718 [PMID:12444712]
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
ChEMBL Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells by fluorescence assay B 5.82 pKi 1500 nM Ki Bioorg. Med. Chem. (2016) 24: 4310-4317 [PMID:27460668]
ChEMBL Displacement of 1,8-ANS from aFABP by fluorescence based-assay B 6.73 pKi 185 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 3511-3515 [PMID:17502136]
ChEMBL Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins B 4.58 pIC50 26100 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 3675-3679 [PMID:20471252]
fatty acid binding protein 5/Fatty acid binding protein epidermal in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3674] [GtoPdb: 2535] [UniProtKB: Q01469]
ChEMBL Displacement of 1,8-ANS from eFABP by fluorescence based-assay B 6.61 pKi 248 nM Ki Bioorg. Med. Chem. Lett. (2007) 17: 3511-3515 [PMID:17502136]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5421] [GtoPdb: 2531] [UniProtKB: P07148]
ChEMBL Binding affinity to L-FABP low binding affinity site by titration calorimetry method B 6.05 pKd 900 nM Kd J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL Binding affinity to L-FABP high binding affinity site by titration calorimetry method B 6.7 pKd 200 nM Kd J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
fatty acid binding protein 1/Fatty acid-binding protein, liver in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5738] [GtoPdb: 2531] [UniProtKB: P02692]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 5.54 pKi 2900 nM Ki J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
ChEMBL Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay B 6.74 pKi 180 nM Ki J. Med. Chem. (2008) 51: 3755-3764 [PMID:18533710]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL Inhibition of PPAR-alpha (unknown origin) by SPA assay B 6.22 pIC50 600 nM IC50 Med Chem Res (2009) 18: 8-19
ChEMBL Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay B 6.22 pIC50 600 nM IC50 Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay B 5.28 pIC50 5300 nM IC50 Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay B 5.39 pIC50 4100 nM IC50 Med Chem Res (2013) 22: 3126-3133
Seed lipoxygenase-1 in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4586] [UniProtKB: P08170]
ChEMBL Binding affinity to soybean LO1 B 4.66 pKi 22000 nM Ki Bioorg. Med. Chem. (2009) 17: 6534-6539 [PMID:19716306]
Telomerase reverse transcriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2916] [UniProtKB: O14746]
ChEMBL Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay B 5.07 pIC50 8600 nM IC50 MedChemComm (2011) 2: 229-245
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3]
GtoPdb - - 4.7 pEC50 - - - Mol. Pharmacol. (2012) 81: 631-42 [PMID:22282525]
FFA1 receptor in Human [GtoPdb: 225] [UniProtKB: O14842]
GtoPdb - - 5.7 pEC50 - - - J. Biol. Chem. (2003) 278: 11303-11 [PMID:12496284];
Biochem. Biophys. Res. Commun. (2003) 301: 406-10 [PMID:12565875];
Nature (2003) 422: 173-6 [PMID:12629551]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]